Simulation scenario 3, CR phase

Setting description

TC2 more effective in the TEfus+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.087, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 11.3, median = 8.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
all	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.28, hr = 0.77	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.098, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10, median = 7.2	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
AR- & TP53-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.14, hr = 0.87	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.084, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 11.7, median = 8.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
HRD+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.33, hr = 0.74	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.071, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.8, median = 9.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.57, hr = 0.62	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
TEfus+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.074, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.3, median = 9.6	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
PI3K+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.52, hr = 0.65	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 7 30 2 5 2 AR- & TP53- 27 59 8 7 5 HRD+ 1 36 7 5 6 TP53+ 0 60 2 0 2 TEfus+ 0 228 0 0 0 PI3K+ 0 63 1 0 4

TC1 TC2 TC3 TC4 TC5 all 0.014 0.060 0.004 0.010 0.004 AR- & TP53- 0.054 0.118 0.016 0.014 0.010 HRD+ 0.002 0.072 0.014 0.010 0.012 TP53+ 0.000 0.120 0.004 0.000 0.004 TEfus+ 0.000 0.456 0.000 0.000 0.000 PI3K+ 0.000 0.126 0.002 0.000 0.008

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 13 0 4 0 5 AR- & TP53- 125 8 121 124 100 HRD+ 23 0 41 52 28 TP53+ 100 0 87 77 109 TEfus+ 92 0 104 90 92 PI3K+ 58 2 59 63 92

TC1 TC2 TC3 TC4 TC5 all 0.026 0.000 0.008 0.000 0.010 AR- & TP53- 0.250 0.016 0.242 0.248 0.200 HRD+ 0.046 0.000 0.082 0.104 0.056 TP53+ 0.200 0.000 0.174 0.154 0.218 TEfus+ 0.184 0.000 0.208 0.180 0.184 PI3K+ 0.116 0.004 0.118 0.126 0.184

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 52 34 41 42 36 HRD+ 0 0 0 0 0 TP53+ 0 1 0 0 0 TEfus+ 0 1 0 0 0 PI3K+ 0 0 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.000 0.000 AR- & TP53- 0.104 0.068 0.082 0.084 0.072 HRD+ 0.000 0.000 0.000 0.000 0.000 TP53+ 0.000 0.002 0.000 0.000 0.000 TEfus+ 0.000 0.002 0.000 0.000 0.000 PI3K+ 0.000 0.000 0.000 0.000 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.342	0.068	0.210	0.04	0.032	0.036
err_type	0.498	0.068	0.406	0.04	0.032	0.036
pow_sign	0.456	0.000	0.456	0.00	0.000	0.000
pow_type	0.666	0.000	0.666	0.00	0.000	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	7	30	2	5	2
all	futility	0	13	0	4	0	5
all	max_n	0	0	0	0	0	0
all	n	375 (336, 417)	160 (93, 220)	169 (93, 235)	157 (99, 218)	158 (101, 220)	156 (98, 213)
all	n_unique	346 (310, 384)	147 (85, 204)	154 (84, 218)	144 (91, 202)	144 (92, 203)	142 (90, 198)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	4 (3, 9)	7 (5, 17)	15 (8, 26)	8 (6, 9)	20 (6, 24)
all	post_p	NA (NA, NA)	0.12 (0.01, 0.51)	1 (0.96, 1)	0.1 (0.01, 0.48)	0.1 (0.01, 0.51)	0.1 (0.01, 0.48)
all	rate	0.098 (0.091, 0.106)	0.113 (0.101, 0.128)	0.069 (0.059, 0.081)	0.114 (0.101, 0.13)	0.113 (0.101, 0.128)	0.113 (0.102, 0.129)
AR- & TP53-	graduation	0	27	59	8	7	5
AR- & TP53-	futility	0	125	8	121	124	100
AR- & TP53-	max_n	0	52	34	41	42	36
AR- & TP53-	n	219 (188, 251)	90 (28, 150)	82 (29, 139)	87 (36, 147)	85 (36, 145)	88 (38, 139)
AR- & TP53-	n_unique	203 (174, 235)	84 (26, 139)	75 (27, 129)	80 (32, 137)	78 (33, 136)	80 (35, 130)
AR- & TP53-	time_trial	36 (36, 36)	36 (8, 36)	36 (15, 36)	36 (19, 36)	36 (18, 36)	36 (21, 36)
AR- & TP53-	time_stop	NA (NA, NA)	11 (6, 28)	11 (9, 19)	21 (12, 33)	21 (12, 31)	21 (12, 33)
AR- & TP53-	post_p	NA (NA, NA)	0.33 (0.04, 0.75)	0.9 (0.48, 0.99)	0.26 (0.03, 0.78)	0.3 (0.04, 0.71)	0.29 (0.04, 0.73)
AR- & TP53-	rate	0.105 (0.096, 0.115)	0.114 (0.098, 0.138)	0.087 (0.072, 0.104)	0.116 (0.098, 0.141)	0.114 (0.099, 0.14)	0.115 (0.099, 0.138)
HRD+	graduation	0	1	36	7	5	6
HRD+	futility	0	23	0	41	52	28
HRD+	max_n	0	0	0	0	0	0
HRD+	n	59 (49, 71)	24 (9, 38)	26 (11, 40)	31 (19, 48)	29 (19, 45)	27 (15, 43)
HRD+	n_unique	54 (44, 66)	21 (8, 35)	24 (9, 37)	28 (17, 44)	27 (18, 41)	24 (13, 38)
HRD+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
HRD+	time_stop	NA (NA, NA)	31 (23, 35)	29 (23, 34)	29 (21, 35)	28 (21, 36)	30 (24, 35)
HRD+	post_p	NA (NA, NA)	0.33 (0.07, 0.73)	0.87 (0.41, 0.99)	0.28 (0.04, 0.71)	0.28 (0.05, 0.69)	0.29 (0.06, 0.7)
HRD+	rate	0.096 (0.079, 0.119)	0.116 (0.085, 0.161)	0.071 (0.05, 0.105)	0.114 (0.092, 0.156)	0.115 (0.091, 0.153)	0.115 (0.088, 0.158)
TP53+	graduation	0	0	60	2	0	2
TP53+	futility	0	100	0	87	77	109
TP53+	max_n	0	0	1	0	0	0
TP53+	n	129 (113, 149)	54 (28, 79)	66 (28, 99)	54 (28, 79)	55 (30, 83)	53 (29, 78)
TP53+	n_unique	118 (102, 137)	49 (26, 71)	60 (25, 92)	48 (26, 72)	50 (28, 76)	48 (26, 71)
TP53+	time_trial	36 (36, 36)	36 (23, 36)	36 (25, 36)	36 (26, 36)	36 (29, 36)	36 (21, 36)
TP53+	time_stop	NA (NA, NA)	23 (15, 34)	15 (11, 28)	25 (16, 34)	27 (17, 34)	22 (14, 32)
TP53+	post_p	NA (NA, NA)	0.12 (0.01, 0.52)	1 (0.93, 1)	0.12 (0.01, 0.49)	0.12 (0.01, 0.48)	0.1 (0.01, 0.46)
TP53+	rate	0.089 (0.078, 0.102)	0.114 (0.094, 0.15)	0.053 (0.042, 0.068)	0.115 (0.094, 0.145)	0.113 (0.095, 0.143)	0.116 (0.095, 0.146)
TEfus+	graduation	0	0	228	0	0	0
TEfus+	futility	0	92	0	104	90	92
TEfus+	max_n	0	0	1	0	0	0
TEfus+	n	123 (108, 142)	47 (27, 73)	69 (26, 107)	49 (30, 75)	50 (32, 78)	51 (30, 74)
TEfus+	n_unique	113 (98, 130)	42 (25, 66)	63 (23, 99)	44 (28, 68)	46 (29, 70)	46 (27, 65)
TEfus+	time_trial	36 (36, 36)	36 (28, 36)	36 (14, 36)	36 (26, 36)	36 (31, 36)	36 (28, 36)
TEfus+	time_stop	NA (NA, NA)	26 (17, 34)	19 (12, 31)	26 (17, 33)	30 (20, 35)	27 (16, 35)
TEfus+	post_p	NA (NA, NA)	0.04 (0, 0.28)	1 (1, 1)	0.03 (0, 0.19)	0.03 (0, 0.23)	0.03 (0, 0.23)
TEfus+	rate	0.075 (0.065, 0.089)	0.114 (0.093, 0.147)	0.036 (0.028, 0.044)	0.116 (0.095, 0.142)	0.114 (0.093, 0.143)	0.115 (0.095, 0.141)
PI3K+	graduation	0	0	63	1	0	4
PI3K+	futility	0	58	2	59	63	92
PI3K+	max_n	0	0	0	0	0	0
PI3K+	n	126 (110, 146)	51 (26, 75)	56 (25, 87)	53 (30, 79)	55 (30, 81)	58 (30, 85)
PI3K+	n_unique	116 (100, 134)	46 (25, 69)	51 (23, 80)	48 (27, 72)	49 (27, 74)	53 (28, 79)
PI3K+	time_trial	36 (36, 36)	36 (33, 36)	36 (25, 36)	36 (32, 36)	36 (31, 36)	36 (17, 36)
PI3K+	time_stop	NA (NA, NA)	26 (17, 33)	20 (13, 28)	24 (17, 34)	24 (18, 34)	16 (11, 30)
PI3K+	post_p	NA (NA, NA)	0.16 (0.02, 0.55)	0.99 (0.86, 1)	0.13 (0.02, 0.54)	0.14 (0.02, 0.55)	0.11 (0.01, 0.46)
PI3K+	rate	0.092 (0.081, 0.105)	0.114 (0.093, 0.143)	0.057 (0.044, 0.073)	0.115 (0.094, 0.142)	0.114 (0.093, 0.142)	0.116 (0.096, 0.142)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	33	86	10	12	7
—–	futility	0	133	8	122	124	101
—–	max_n	0	52	34	41	42	36
—–	n	124 (100, 151)	44 (18, 99)	38 (13, 94)	38 (10, 93)	42 (11, 92)	38 (10, 87)
—–	n_unique	117 (92, 141)	41 (17, 95)	36 (12, 89)	36 (9, 88)	39 (10, 88)	36 (9, 84)
—–	post_p	NA (NA, NA)	0.49 (0.13, 0.88)	0.48 (0.12, 0.89)	0.44 (0.1, 0.88)	0.46 (0.1, 0.87)	0.42 (0.09, 0.87)
—–	rate	0.114 (0.1, 0.128)	0.116 (0.096, 0.153)	0.115 (0.094, 0.166)	0.117 (0.095, 0.179)	0.118 (0.095, 0.175)	0.119 (0.094, 0.194)
—-+	graduation	0	31	128	11	12	11
—-+	futility	0	167	10	151	157	161
—-+	max_n	0	52	34	40	42	36
—-+	n	31 (23, 40)	9 (3, 25)	8 (2, 21)	11 (4, 27)	10 (3, 24)	13 (5, 28)
—-+	n_unique	28 (21, 38)	8 (3, 24)	7 (2, 19)	10 (3, 24)	9 (3, 22)	13 (4, 26)
—-+	post_p	NA (NA, NA)	0.44 (0.17, 0.87)	0.45 (0.16, 0.83)	0.46 (0.16, 0.85)	0.44 (0.16, 0.84)	0.46 (0.16, 0.84)
—-+	rate	0.113 (0.087, 0.146)	0.122 (0.077, 0.261)	0.123 (0.074, 0.278)	0.123 (0.081, 0.246)	0.123 (0.082, 0.255)	0.12 (0.087, 0.208)
—+-	graduation	0	30	266	8	11	7
—+-	futility	0	189	7	185	174	156
—+-	max_n	0	50	33	38	39	34
—+-	n	5 (2, 9)	2 (0, 5)	2 (0, 6)	2 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	n_unique	5 (2, 8)	2 (0, 5)	2 (0, 6)	2 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	post_p	NA (NA, NA)	0.42 (0.24, 0.59)	0.7 (0.45, 0.9)	0.41 (0.26, 0.62)	0.42 (0.25, 0.62)	0.41 (0.23, 0.64)
—+-	rate	0.078 (0.03, 0.187)	0.131 (0.059, 0.495)	0.032 (0, 0.131)	0.137 (0.046, 0.397)	0.135 (0.047, 0.537)	0.132 (0.049, 0.499)
—++	graduation	0	28	286	9	11	11
—++	futility	0	209	9	203	197	198
—++	max_n	0	50	33	38	39	34
—++	n	14 (10, 19)	4 (1, 11)	5 (1, 13)	4 (1, 11)	5 (1, 12)	6 (3, 12)
—++	n_unique	13 (8, 18)	4 (1, 10)	4 (0, 12)	4 (1, 10)	4 (1, 11)	5 (2, 11)
—++	post_p	NA (NA, NA)	0.36 (0.16, 0.64)	0.83 (0.47, 0.98)	0.34 (0.16, 0.61)	0.35 (0.17, 0.62)	0.32 (0.16, 0.61)
—++	rate	0.077 (0.049, 0.123)	0.123 (0.07, 0.296)	0.036 (0.01, 0.108)	0.133 (0.069, 0.45)	0.131 (0.07, 0.36)	0.129 (0.076, 0.259)
–+–	graduation	0	7	86	4	5	4
–+–	futility	0	112	0	89	77	110
–+–	max_n	0	0	1	0	0	0
–+–	n	26 (18, 35)	11 (4, 25)	9 (3, 22)	10 (3, 22)	10 (3, 24)	10 (4, 22)
–+–	n_unique	24 (17, 32)	11 (4, 22)	8 (3, 20)	9 (3, 21)	9 (3, 22)	9 (3, 21)
–+–	post_p	NA (NA, NA)	0.45 (0.16, 0.85)	0.47 (0.16, 0.81)	0.43 (0.17, 0.84)	0.46 (0.16, 0.83)	0.43 (0.18, 0.87)
–+–	rate	0.113 (0.084, 0.147)	0.12 (0.085, 0.233)	0.123 (0.079, 0.264)	0.129 (0.081, 0.271)	0.119 (0.082, 0.288)	0.124 (0.077, 0.249)
–+-+	graduation	0	7	135	5	5	7
–+-+	futility	0	142	2	122	115	163
–+-+	max_n	0	0	1	0	0	0
–+-+	n	26 (19, 33)	10 (3, 22)	7 (3, 20)	10 (3, 22)	10 (3, 23)	10 (4, 24)
–+-+	n_unique	23 (17, 32)	9 (3, 20)	6 (2, 18)	9 (3, 20)	9 (3, 21)	9 (4, 22)
–+-+	post_p	NA (NA, NA)	0.46 (0.17, 0.86)	0.47 (0.17, 0.85)	0.45 (0.18, 0.83)	0.47 (0.19, 0.84)	0.42 (0.13, 0.83)
–+-+	rate	0.113 (0.083, 0.151)	0.119 (0.078, 0.266)	0.12 (0.078, 0.282)	0.123 (0.079, 0.261)	0.125 (0.08, 0.264)	0.127 (0.083, 0.254)
–++-	graduation	0	7	277	4	5	4
–++-	futility	0	171	0	158	141	167
–++-	max_n	0	0	2	0	0	0
–++-	n	7 (4, 11)	3 (1, 6)	4 (1, 10)	3 (1, 7)	3 (1, 6)	3 (1, 6)
–++-	n_unique	7 (3, 11)	3 (1, 6)	4 (1, 9)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	post_p	NA (NA, NA)	0.38 (0.22, 0.65)	0.75 (0.46, 0.95)	0.38 (0.2, 0.65)	0.39 (0.22, 0.62)	0.4 (0.22, 0.63)
–++-	rate	0.076 (0.042, 0.154)	0.133 (0.057, 0.42)	0.039 (0.008, 0.103)	0.138 (0.055, 0.455)	0.126 (0.057, 0.355)	0.137 (0.057, 0.411)
–+++	graduation	0	7	300	5	5	7
–+++	futility	0	193	2	181	167	208
–+++	max_n	0	0	2	0	0	0
–+++	n	21 (15, 29)	6 (2, 15)	10 (2, 22)	6 (2, 15)	6 (3, 17)	7 (3, 15)
–+++	n_unique	20 (13, 27)	6 (2, 13)	9 (2, 20)	5 (2, 14)	6 (2, 15)	6 (3, 14)
–+++	post_p	NA (NA, NA)	0.29 (0.11, 0.62)	0.93 (0.62, 1)	0.3 (0.13, 0.62)	0.3 (0.12, 0.61)	0.28 (0.1, 0.59)
–+++	rate	0.079 (0.053, 0.115)	0.132 (0.073, 0.309)	0.037 (0.019, 0.07)	0.125 (0.072, 0.318)	0.132 (0.074, 0.308)	0.125 (0.079, 0.247)
-+—	graduation	0	34	121	17	16	12
-+—	futility	0	150	8	149	160	125
-+—	max_n	0	52	34	39	39	35
-+—	n	26 (19, 33)	7 (1, 19)	9 (2, 19)	11 (4, 26)	10 (4, 22)	10 (3, 22)
-+—	n_unique	23 (17, 31)	6 (1, 18)	8 (2, 18)	10 (4, 24)	9 (4, 21)	9 (3, 20)
-+—	post_p	NA (NA, NA)	0.44 (0.18, 0.83)	0.48 (0.17, 0.84)	0.48 (0.17, 0.85)	0.45 (0.15, 0.82)	0.43 (0.18, 0.82)
-+—	rate	0.113 (0.087, 0.154)	0.125 (0.078, 0.356)	0.12 (0.08, 0.268)	0.122 (0.083, 0.222)	0.124 (0.085, 0.236)	0.125 (0.084, 0.273)
-+–+	graduation	0	32	156	18	16	16
-+–+	futility	0	183	10	174	191	179
-+–+	max_n	0	52	34	38	39	35
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	0.51 (0.46, 0.55)	NA (NA, NA)	0.58 (0.58, 0.58)	0.51 (0.48, 0.53)	0.5 (0.45, 0.54)
-+–+	rate	0.089 (0, 0.501)	0.118 (0.009, 0.467)	0.077 (0, 0.458)	0.144 (0.013, 2.434)	0.134 (0, 0.578)	0.12 (0, 6.39)
-+-+-	graduation	0	31	280	14	15	11
-+-+-	futility	0	203	7	202	203	178
-+-+-	max_n	0	50	33	36	36	33
-+-+-	n	13 (8, 19)	4 (0, 10)	4 (1, 13)	5 (2, 11)	5 (2, 11)	5 (2, 11)
-+-+-	n_unique	12 (7, 17)	3 (0, 9)	4 (0, 12)	5 (2, 10)	5 (2, 11)	4 (1, 10)
-+-+-	post_p	NA (NA, NA)	0.38 (0.21, 0.66)	0.84 (0.48, 0.98)	0.32 (0.14, 0.58)	0.33 (0.15, 0.63)	0.34 (0.17, 0.63)
-+-+-	rate	0.077 (0.046, 0.133)	0.119 (0.061, 0.346)	0.034 (0.01, 0.103)	0.129 (0.076, 0.305)	0.128 (0.071, 0.327)	0.125 (0.066, 0.335)
-+-++	graduation	0	29	300	15	15	15
-+-++	futility	0	222	9	216	225	215
-+-++	max_n	0	50	33	36	36	33
-+-++	n	5 (2, 9)	2 (0, 5)	2 (0, 5)	3 (1, 6)	3 (1, 6)	2 (0, 5)
-+-++	n_unique	5 (2, 8)	1 (0, 4)	2 (0, 5)	2 (0, 5)	2 (1, 5)	2 (0, 5)
-+-++	post_p	NA (NA, NA)	0.42 (0.25, 0.66)	0.68 (0.43, 0.88)	0.4 (0.23, 0.63)	0.41 (0.23, 0.64)	0.41 (0.26, 0.63)
-+-++	rate	0.077 (0.03, 0.188)	0.144 (0.049, 0.575)	0.041 (0, 0.146)	0.135 (0.059, 0.394)	0.13 (0.057, 0.383)	0.139 (0.056, 0.462)
-++–	graduation	0	7	118	11	9	10
-++–	futility	0	133	0	122	117	130
-++–	max_n	0	0	1	0	0	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.51 (0.48, 0.53)	0.47 (0.43, 0.5)	0.49 (0.49, 0.49)	0.47 (0.4, 0.55)	NA (NA, NA)
-++–	rate	0.108 (0, 0.535)	0.107 (0, 1.295)	0.099 (0, 0.391)	0.122 (0, 0.732)	0.121 (0, 0.371)	0.091 (0, 0.806)
-++-+	graduation	0	7	163	12	9	13
-++-+	futility	0	160	2	150	150	180
-++-+	max_n	0	0	1	0	0	0
-++-+	n	3 (1, 5)	1 (0, 3)	1 (0, 3)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++-+	n_unique	2 (0, 5)	1 (0, 3)	1 (0, 3)	1 (0, 4)	1 (0, 4)	1 (0, 3)
-++-+	post_p	NA (NA, NA)	0.47 (0.31, 0.68)	0.47 (0.33, 0.73)	0.49 (0.33, 0.71)	0.46 (0.32, 0.68)	0.47 (0.34, 0.71)
-++-+	rate	0.12 (0.035, 0.43)	0.158 (0.04, 0.779)	0.135 (0.024, 0.591)	0.127 (0.034, 0.467)	0.137 (0.043, 0.465)	0.139 (0, 0.576)
-+++-	graduation	0	7	292	10	8	9
-+++-	futility	0	189	0	182	173	184
-+++-	max_n	0	0	2	0	0	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.43 (0.4, 0.44)	0.54 (0.53, 0.55)	0.54 (0.54, 0.54)	0.48 (0.46, 0.58)	NA (NA, NA)
-+++-	rate	0.159 (0, 0.616)	0.114 (0, 1.49)	0.051 (0, 0.404)	0.185 (0, 1.235)	0.18 (0, 0.456)	0.205 (0.006, 9.89)
-++++	graduation	0	7	315	11	8	12
-++++	futility	0	209	2	200	195	222
-++++	max_n	0	0	2	0	0	0
-++++	n	3 (1, 6)	1 (0, 3)	1 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++++	n_unique	3 (1, 5)	1 (0, 3)	1 (0, 3)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++++	post_p	NA (NA, NA)	0.44 (0.3, 0.64)	0.63 (0.44, 0.82)	0.44 (0.29, 0.62)	0.43 (0.28, 0.62)	0.44 (0.31, 0.63)
-++++	rate	0.077 (0, 0.261)	0.136 (0.033, 0.572)	0.037 (0, 0.198)	0.134 (0.036, 0.472)	0.135 (0.045, 0.523)	0.14 (0.036, 0.607)
+—-	graduation	0	7	30	2	5	2
+—-	futility	0	13	0	4	0	5
+—-	max_n	0	0	0	0	0	0
+—-	n	5 (2, 8)	3 (1, 6)	3 (1, 6)	2 (1, 5)	2 (0, 5)	2 (1, 5)
+—-	n_unique	4 (1, 7)	2 (1, 5)	2 (1, 5)	2 (0, 4)	2 (0, 5)	2 (0, 5)
+—-	post_p	NA (NA, NA)	0.49 (0.3, 0.76)	0.47 (0.25, 0.74)	0.47 (0.29, 0.75)	0.48 (0.27, 0.73)	0.49 (0.28, 0.74)
+—-	rate	0.115 (0.059, 0.271)	0.131 (0.049, 0.44)	0.134 (0.054, 0.474)	0.137 (0.046, 0.562)	0.135 (0.039, 0.475)	0.131 (0.044, 0.476)
+—+	graduation	0	7	90	3	5	6
+—+	futility	0	71	2	60	63	93
+—+	max_n	0	0	0	0	0	0
+—+	n	2 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	n_unique	1 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	post_p	NA (NA, NA)	0.48 (0.33, 0.65)	0.48 (0.36, 0.69)	0.48 (0.35, 0.65)	0.48 (0.35, 0.68)	0.49 (0.33, 0.67)
+—+	rate	0.128 (0, 0.543)	0.135 (0, 0.49)	0.132 (0.044, 0.639)	0.141 (0, 0.77)	0.133 (0, 0.73)	0.124 (0, 0.524)
+–+-	graduation	0	7	254	2	5	2
+–+-	futility	0	104	0	106	90	94
+–+-	max_n	0	0	1	0	0	0
+–+-	n	7 (4, 12)	3 (1, 7)	4 (1, 10)	3 (1, 7)	3 (1, 6)	3 (1, 7)
+–+-	n_unique	7 (3, 11)	3 (1, 6)	4 (1, 9)	3 (1, 6)	3 (1, 6)	3 (1, 6)
+–+-	post_p	NA (NA, NA)	0.37 (0.21, 0.62)	0.78 (0.5, 0.95)	0.4 (0.21, 0.67)	0.39 (0.21, 0.64)	0.39 (0.21, 0.65)
+–+-	rate	0.081 (0.041, 0.145)	0.138 (0.058, 0.328)	0.037 (0.013, 0.089)	0.124 (0.05, 0.382)	0.128 (0.049, 0.408)	0.128 (0.052, 0.383)
+–++	graduation	0	7	282	3	5	6
+–++	futility	0	139	2	140	129	152
+–++	max_n	0	0	1	0	0	0
+–++	n	4 (1, 7)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 5)
+–++	n_unique	3 (1, 6)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)
+–++	post_p	NA (NA, NA)	0.43 (0.29, 0.63)	0.64 (0.44, 0.84)	0.43 (0.28, 0.62)	0.44 (0.29, 0.64)	0.44 (0.28, 0.64)
+–++	rate	0.072 (0, 0.195)	0.135 (0.045, 0.496)	0.041 (0, 0.162)	0.132 (0.048, 0.563)	0.128 (0.038, 0.474)	0.132 (0.052, 0.42)
+-+–	graduation	0	7	86	4	5	4
+-+–	futility	0	112	0	89	77	110
+-+–	max_n	0	0	1	0	0	0
+-+–	n	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.49 (0.38, 0.65)	0.48 (0.35, 0.66)	0.48 (0.36, 0.63)	0.49 (0.37, 0.63)	0.49 (0.39, 0.65)
+-+–	rate	0.129 (0, 0.461)	0.124 (0, 0.522)	0.128 (0, 0.793)	0.154 (0.03, 0.65)	0.138 (0, 0.69)	0.135 (0, 0.557)
+-+-+	graduation	0	7	135	5	5	7
+-+-+	futility	0	142	2	122	115	163
+-+-+	max_n	0	0	1	0	0	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	0.48 (0.48, 0.48)	0.5 (0.5, 0.5)	0.63 (0.63, 0.63)
+-+-+	rate	0.321 (0.043, 3.94)	0.182 (0, 0.504)	0.147 (0, 0.811)	0.146 (0, 0.923)	0.081 (0, 0.929)	0.069 (0, 0.78)
+-++-	graduation	0	7	277	4	5	4
+-++-	futility	0	171	0	158	141	167
+-++-	max_n	0	0	2	0	0	0
+-++-	n	23 (16, 31)	6 (3, 15)	13 (5, 26)	7 (3, 15)	7 (3, 16)	6 (3, 15)
+-++-	n_unique	21 (15, 29)	6 (2, 14)	12 (4, 24)	6 (2, 13)	6 (3, 14)	6 (2, 13)
+-++-	post_p	NA (NA, NA)	0.28 (0.11, 0.58)	0.95 (0.71, 1)	0.26 (0.11, 0.56)	0.26 (0.12, 0.55)	0.28 (0.12, 0.58)
+-++-	rate	0.074 (0.051, 0.112)	0.126 (0.075, 0.284)	0.036 (0.02, 0.061)	0.129 (0.079, 0.276)	0.129 (0.078, 0.275)	0.123 (0.075, 0.291)
+-+++	graduation	0	7	300	5	5	7
+-+++	futility	0	193	2	181	167	208
+-+++	max_n	0	0	2	0	0	0
+-+++	n	17 (11, 24)	5 (2, 13)	8 (2, 20)	6 (2, 14)	6 (2, 15)	6 (3, 12)
+-+++	n_unique	16 (10, 22)	4 (1, 12)	8 (2, 18)	5 (2, 13)	5 (2, 13)	5 (2, 11)
+-+++	post_p	NA (NA, NA)	0.32 (0.15, 0.58)	0.9 (0.59, 0.99)	0.3 (0.14, 0.6)	0.32 (0.13, 0.63)	0.3 (0.13, 0.56)
+-+++	rate	0.076 (0.048, 0.113)	0.128 (0.075, 0.315)	0.037 (0.017, 0.069)	0.128 (0.075, 0.297)	0.125 (0.073, 0.289)	0.129 (0.079, 0.293)
++—	graduation	0	8	66	9	10	8
++—	futility	0	36	0	44	52	33
++—	max_n	0	0	0	0	0	0
++—	n	8 (4, 12)	3 (1, 8)	4 (1, 7)	4 (2, 8)	4 (2, 9)	4 (1, 8)
++—	n_unique	7 (3, 11)	3 (1, 7)	3 (1, 7)	4 (1, 8)	4 (2, 8)	3 (1, 7)
++—	post_p	NA (NA, NA)	0.47 (0.24, 0.78)	0.47 (0.24, 0.79)	0.48 (0.25, 0.81)	0.5 (0.24, 0.8)	0.47 (0.27, 0.79)
++—	rate	0.117 (0.065, 0.208)	0.13 (0.054, 0.402)	0.125 (0.053, 0.382)	0.121 (0.065, 0.302)	0.121 (0.061, 0.313)	0.126 (0.057, 0.366)
++–+	graduation	0	8	119	10	10	12
++–+	futility	0	91	2	94	105	114
++–+	max_n	0	0	0	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	0.53 (0.53, 0.53)	0.49 (0.49, 0.49)	0.5 (0.48, 0.53)	0.51 (0.49, 0.53)	0.47 (0.42, 0.55)
++–+	rate	0.1 (0, 0.964)	0.141 (0, 0.905)	0.09 (0, 0.389)	0.163 (0.018, 0.506)	0.169 (0, 3.103)	0.107 (0, 0.412)
++-+-	graduation	0	8	269	8	9	7
++-+-	futility	0	123	0	135	127	118
++-+-	max_n	0	0	1	0	0	0
++-+-	n	1 (0, 2)	0 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 2)
++-+-	n_unique	1 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	post_p	NA (NA, NA)	0.47 (0.39, 0.61)	0.55 (0.44, 0.65)	0.46 (0.39, 0.58)	0.46 (0.39, 0.59)	0.47 (0.39, 0.57)
++-+-	rate	0.074 (0, 0.594)	0.138 (0, 0.639)	0.03 (0, 0.257)	0.15 (0, 0.638)	0.147 (0, 0.716)	0.14 (0, 0.849)
++-++	graduation	0	8	297	9	9	11
++-++	futility	0	156	2	163	162	170
++-++	max_n	0	0	1	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.47, 0.54)	0.45 (0.44, 0.46)	NA (NA, NA)
++-++	rate	0.059 (0, 0.214)	0.213 (0, 0.428)	0 (0, 4.894)	0.179 (0, 1.008)	0.099 (0, 0.445)	0.139 (0, 0.711)
+++–	graduation	0	7	118	11	9	10
+++–	futility	0	133	0	122	117	130
+++–	max_n	0	0	1	0	0	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.51 (0.46, 0.61)	0.5 (0.43, 0.55)	0.48 (0.42, 0.58)	0.49 (0.44, 0.56)	0.47 (0.38, 0.53)
+++–	rate	0.137 (0, 0.573)	0.114 (0, 0.932)	0.147 (0, 0.684)	0.154 (0, 1.146)	0.132 (0, 0.795)	0.134 (0, 0.712)
+++-+	graduation	0	7	163	12	9	13
+++-+	futility	0	160	2	150	150	180
+++-+	max_n	0	0	1	0	0	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.48 (0.44, 0.52)	NA (NA, NA)	0.56 (0.52, 0.6)	0.52 (0.44, 0.55)	0.46 (0.45, 0.53)
+++-+	rate	0.177 (0, 3.068)	0.156 (0.012, 0.831)	0.09 (0, 0.679)	0.101 (0, 0.677)	0.16 (0.028, 0.674)	0.171 (0, 1.359)
++++-	graduation	0	7	292	10	8	9
++++-	futility	0	189	0	182	173	184
++++-	max_n	0	0	2	0	0	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	0.55 (0.44, 0.65)	0.48 (0.47, 0.48)	0.46 (0.38, 0.46)	0.47 (0.45, 0.47)	0.55 (0.53, 0.58)
++++-	rate	0.104 (0, 0.457)	0.129 (0, 0.691)	0.062 (0, 0.951)	0.178 (0.032, 1.048)	0.155 (0, 0.393)	0.146 (0, 0.996)
+++++	graduation	0	7	315	11	8	12
+++++	futility	0	209	2	200	195	222
+++++	max_n	0	0	2	0	0	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	NA (NA, NA)	0.56 (0.56, 0.56)	0.51 (0.48, 0.54)	NA (NA, NA)	0.46 (0.46, 0.46)
+++++	rate	0.051 (0, 0.479)	0.149 (0.046, 1.098)	0 (0, 0.103)	0.182 (0, 1.453)	0.141 (0, 0.51)	0.178 (0.046, 1.036)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	7	30	2	5	2
all	time_stop	4 (3, 6)	7 (5, 17)	8 (7, 8)	8 (6, 9)	6 (6, 7)
all	n_trt	27 (25, 35)	33 (27, 73)	29 (26, 32)	29 (28, 44)	25 (25, 25)
all	n_control	49 (32, 65)	63 (42, 148)	76 (74, 78)	67 (51, 71)	70 (63, 77)
all	post_p	0.92 (0.88, 0.93)	0.97 (0.88, 1)	0.94 (0.92, 0.97)	0.94 (0.88, 0.95)	0.96 (0.94, 0.98)
all	order	1 (1, 1.4)	1 (1, 2.1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
AR- & TP53-	count	27	59	8	7	5
AR- & TP53-	time_stop	7 (6, 9)	10 (8, 19)	10 (8, 12)	11 (9, 16)	13 (10, 17)
AR- & TP53-	n_trt	31 (26, 43)	33 (26, 58)	28 (25, 36)	27 (26, 54)	43 (32, 47)
AR- & TP53-	n_control	39 (33, 53)	57 (42, 91)	48 (42, 68)	61 (54, 90)	70 (51, 95)
AR- & TP53-	post_p	0.9 (0.86, 0.95)	0.93 (0.86, 0.98)	0.93 (0.87, 0.96)	0.96 (0.88, 0.98)	0.95 (0.92, 0.95)
AR- & TP53-	order	1 (1, 1)	1 (1, 2)	1 (1, 2)	1 (1, 1.4)	1 (1, 2)
HRD+	count	1	36	7	5	6
HRD+	time_stop	23 (23, 23)	29 (23, 34)	21 (19, 30)	20 (19, 25)	26 (20, 32)
HRD+	n_trt	25 (25, 25)	27 (25, 38)	27 (25, 35)	28 (25, 43)	26 (26, 31)
HRD+	n_control	40 (40, 40)	42 (28, 56)	34 (26, 53)	34 (27, 46)	35 (31, 42)
HRD+	post_p	0.92 (0.92, 0.92)	0.97 (0.89, 1)	0.93 (0.87, 0.95)	0.94 (0.88, 0.98)	0.9 (0.87, 0.92)
HRD+	order	2 (2, 2)	2 (1, 3)	1 (1, 2)	2 (2, 3)	2.5 (1, 3)
TP53+	count		60	2		2
TP53+	time_stop		15 (11, 28)	16 (16, 16)		11 (10, 12)
TP53+	n_trt		30 (25, 52)	28 (27, 28)		26 (25, 27)
TP53+	n_control		49 (31, 91)	46 (44, 48)		34 (34, 34)
TP53+	post_p		0.99 (0.93, 1)	0.95 (0.95, 0.95)		0.96 (0.95, 0.96)
TP53+	order		1 (1, 2)	2.5 (2.1, 2.9)		1.5 (1.1, 1.9)
TEfus+	count		228
TEfus+	time_stop		19 (12, 31)
TEfus+	n_trt		40 (25, 80)
TEfus+	n_control		56 (31, 99)
TEfus+	post_p		1 (0.98, 1)
TEfus+	order		1 (1, 2)
PI3K+	count		63	1		4
PI3K+	time_stop		20 (13, 28)	15 (15, 15)		14 (10, 14)
PI3K+	n_trt		32 (25, 57)	28 (28, 28)		26 (26, 35)
PI3K+	n_control		57 (32, 95)	49 (49, 49)		44 (29, 47)
PI3K+	post_p		0.98 (0.93, 1)	0.97 (0.97, 0.97)		0.9 (0.9, 0.94)
PI3K+	order		2 (1, 3)	1 (1, 1)		1.5 (1, 2)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	13		4		5
all	time_stop	4 (3, 11)		22 (13, 28)		22 (12, 25)
all	n_trt	28 (25, 55)		64 (40, 82)		74 (40, 107)
all	n_control	42 (30, 88)		199 (118, 299)		212 (106, 260)
all	post_p	0.08 (0, 0.22)		0 (0, 0.01)		0.01 (0, 0.02)
all	order	1 (1, 1.8)		1.5 (1, 6.2)		4 (2.2, 7.2)
AR- & TP53-	count	125	8	121	124	100
AR- & TP53-	time_stop	13 (6, 30)	12 (9, 18)	21 (13, 33)	22 (13, 31)	21 (12, 33)
AR- & TP53-	n_trt	36 (26, 78)	27 (26, 40)	45 (26, 90)	46 (26, 85)	42 (26, 80)
AR- & TP53-	n_control	66 (32, 173)	70 (43, 81)	122 (66, 206)	118 (72, 181)	119 (61, 194)
AR- & TP53-	post_p	0.12 (0.02, 0.25)	0.14 (0.03, 0.25)	0.07 (0.01, 0.2)	0.1 (0.02, 0.2)	0.09 (0.02, 0.21)
AR- & TP53-	order	1 (1, 3)	1 (1, 2.3)	2 (1, 5)	2 (1, 4)	2 (1, 4.1)
HRD+	count	23		41	52	28
HRD+	time_stop	32 (24, 35)		29 (24, 35)	29 (21, 36)	30 (26, 35)
HRD+	n_trt	27 (25, 38)		29 (25, 41)	27 (25, 33)	27 (25, 33)
HRD+	n_control	49 (32, 60)		45 (30, 60)	43 (28, 60)	49 (34, 63)
HRD+	post_p	0.09 (0.04, 0.19)		0.14 (0.04, 0.29)	0.09 (0.03, 0.22)	0.08 (0.02, 0.22)
HRD+	order	3 (1, 4.8)		4 (2, 7)	3 (1, 5)	3 (2, 5)
TP53+	count	100		87	77	109
TP53+	time_stop	23 (15, 34)		25 (17, 34)	27 (17, 34)	22 (14, 32)
TP53+	n_trt	35 (25, 53)		29 (25, 50)	32 (25, 54)	33 (26, 49)
TP53+	n_control	72 (40, 115)		80 (49, 115)	89 (47, 121)	65 (36, 116)
TP53+	post_p	0.04 (0, 0.13)		0.03 (0, 0.14)	0.04 (0, 0.18)	0.05 (0.01, 0.18)
TP53+	order	2 (1, 5)		2 (1, 4.4)	2 (1, 5)	2 (1, 4)
TEfus+	count	92		104	90	92
TEfus+	time_stop	26 (17, 34)		26 (17, 33)	30 (20, 35)	27 (16, 35)
TEfus+	n_trt	33 (25, 57)		34 (25, 52)	37 (27, 63)	37 (25, 53)
TEfus+	n_control	80 (45, 121)		82 (47, 119)	98 (57, 125)	82 (42, 122)
TEfus+	post_p	0.01 (0, 0.08)		0.01 (0, 0.06)	0.01 (0, 0.05)	0.02 (0, 0.11)
TEfus+	order	3 (1, 5)		3 (1, 5)	3 (1, 6)	3 (1, 6)
PI3K+	count	58	2	59	63	92
PI3K+	time_stop	26 (17, 33)	18 (16, 20)	24 (18, 34)	24 (18, 34)	17 (11, 31)
PI3K+	n_trt	33 (25, 44)	27 (25, 29)	32 (25, 49)	32 (26, 53)	30 (25, 52)
PI3K+	n_control	81 (45, 120)	70 (69, 70)	76 (47, 121)	75 (53, 109)	47 (26, 104)
PI3K+	post_p	0.04 (0.01, 0.13)	0.14 (0.03, 0.25)	0.03 (0.01, 0.17)	0.04 (0, 0.16)	0.06 (0.01, 0.21)
PI3K+	order	3 (1, 5.3)	1.5 (1.1, 1.9)	3 (1.8, 6)	3 (1.2, 5)	2 (1, 4.9)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7
all	TC1	time	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)
all	TC1	n	18 (14, 20)	1 (1, 3)	1 (1, 1)	0 (0, 2)	3 (1, 4)	2 (1, 3)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.78 (0.6, 0.87)	0.53 (0.52, 0.54)	0.51 (0.51, 0.51)	0.56 (0.53, 0.58)	0.55 (0.52, 0.58)	0.53 (0.52, 0.53)	0.51 (0.5, 0.52)	0.52 (0.51, 0.53)	0.52 (0.52, 0.52)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	0.54 (0.53, 0.56)	0.51 (0.51, 0.51)	0.51 (0.5, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.053 (0.03, 0.072)	0 (0, 0.07)	0 (0, 0.075)	0 (0, 0)	0 (0, 0.113)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30	30
all	TC2	time	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)	7 (5, 17)
all	TC2	n	12 (5, 26)	2 (0, 5)	0 (0, 2)	1 (0, 3)	3 (1, 7)	1 (0, 4)	2 (0, 5)	2 (0, 4)	2 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)	1 (0, 2)	0 (0, 1)	2 (0, 4)	0 (0, 2)	0 (0, 1)	0 (0, 0)	5 (2, 7)	3 (1, 5)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.6 (0.51, 0.85)	0.58 (0.51, 0.77)	0.57 (0.55, 0.75)	0.55 (0.5, 0.75)	0.55 (0.51, 0.69)	0.56 (0.51, 0.66)	0.54 (0.51, 0.7)	0.55 (0.53, 0.78)	0.55 (0.52, 0.79)	NA (NA, NA)	0.56 (0.54, 0.7)	0.6 (0.55, 0.74)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	0.56 (0.52, 0.67)	0.53 (0.5, 0.56)	0.62 (0.54, 0.82)	0.55 (0.5, 0.69)	0.58 (0.51, 0.65)	0.55 (0.51, 0.56)	NA (NA, NA)	0.58 (0.52, 0.75)	0.58 (0.52, 0.7)	0.6 (0.53, 0.66)	NA (NA, NA)	0.55 (0.53, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.084 (0.047, 0.127)	0 (0, 0.088)	0 (0, 0.163)	0 (0, 0.036)	0 (0, 0.129)	0.053 (0, 0.117)	0 (0, 0.083)	0 (0, 0.059)	0 (0, 0.127)	NA (NA, NA)	0 (0, 0.031)	0 (0, 0.112)	NA (NA, NA)	0 (0, 0.164)	NA (NA, NA)	0 (0, 0.037)	0 (0, 0.176)	0.184 (0, 1.003)	0 (0, 0.018)	0 (0, 0.079)	0 (0, 0)	0.075 (0.075, 0.075)	0 (0, 0.06)	0 (0, 0.062)	0 (0, 0.147)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC3	time	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)	8 (7, 8)
all	TC3	n	7 (6, 8)	0 (0, 1)	0 (0, 1)	0 (0, 0)	1 (1, 1)	3 (3, 3)	2 (1, 2)	2 (1, 3)	3 (1, 5)	0 (0, 0)	2 (2, 2)	2 (1, 3)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (1, 4)	0 (0, 1)	2 (1, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.55 (0.51, 0.59)	NA (NA, NA)	0.57 (0.57, 0.57)	NA (NA, NA)	0.54 (0.51, 0.58)	0.6 (0.58, 0.62)	0.53 (0.53, 0.53)	0.56 (0.53, 0.59)	0.62 (0.6, 0.65)	NA (NA, NA)	0.57 (0.53, 0.62)	0.52 (0.52, 0.52)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.56 (0.55, 0.56)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.101 (0.098, 0.105)	0.672 (0.672, 0.672)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.245 (0.049, 0.441)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.031 (0.006, 0.056)	0 (0, 0)	0.047 (0.009, 0.085)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC4	time	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)
all	TC4	n	8 (4, 12)	2 (0, 2)	0 (0, 0)	1 (0, 2)	2 (1, 3)	1 (0, 3)	1 (0, 2)	1 (0, 5)	4 (3, 7)	0 (0, 0)	3 (1, 5)	1 (0, 4)	0 (0, 0)	0 (0, 1)	0 (0, 0)	2 (1, 2)	0 (0, 0)	0 (0, 0)	1 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	1 (0, 4)	0 (0, 1)	3 (1, 4)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.69 (0.63, 0.72)	0.59 (0.55, 0.64)	NA (NA, NA)	0.55 (0.52, 0.55)	0.54 (0.53, 0.56)	0.62 (0.57, 0.63)	0.56 (0.55, 0.58)	0.54 (0.53, 0.56)	0.58 (0.57, 0.68)	NA (NA, NA)	0.63 (0.56, 0.8)	0.61 (0.61, 0.61)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.57 (0.52, 0.6)	0.55 (0.55, 0.56)	0.64 (0.59, 0.64)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0 (0, 0.051)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0.176)	0 (0, 0.057)	0 (0, 0)	0.082 (0.016, 0.084)	0.049 (0.018, 0.12)	NA (NA, NA)	0.031 (0, 0.083)	0.091 (0.018, 0.214)	NA (NA, NA)	0.106 (0.021, 0.192)	NA (NA, NA)	0.092 (0.022, 0.316)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.333 (0.067, 0.599)	1.307 (1.307, 1.307)	NA (NA, NA)	0 (0, 0.052)	0 (0, 0)	0 (0, 0.109)	NA (NA, NA)	0.169 (0.034, 0.304)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC5	time	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)
all	TC5	n	4 (2, 6)	4 (4, 5)	0 (0, 0)	3 (2, 4)	0 (0, 1)	2 (1, 4)	0 (0, 1)	6 (4, 7)	0 (0, 1)	0 (0, 0)	1 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.52 (0.5, 0.54)	0.58 (0.53, 0.62)	NA (NA, NA)	0.59 (0.54, 0.64)	0.62 (0.62, 0.62)	0.54 (0.52, 0.55)	0.53 (0.53, 0.53)	0.57 (0.53, 0.61)	0.52 (0.52, 0.52)	NA (NA, NA)	0.54 (0.54, 0.54)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	0.54 (0.51, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.081 (0.016, 0.146)	0.082 (0.06, 0.104)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.038 (0.008, 0.068)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	27	27	27	27					27	27	27	27
AR- & TP53-	TC1	time	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)					7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)
AR- & TP53-	TC1	n	23 (17, 33)	3 (1, 6)	1 (0, 2)	1 (0, 3)					1 (0, 3)	0 (0, 0)	1 (0, 2)	0 (0, 1)
AR- & TP53-	TC1	post_p	0.81 (0.74, 0.94)	0.54 (0.51, 0.72)	0.55 (0.52, 0.61)	0.54 (0.52, 0.6)					0.57 (0.52, 0.66)	NA (NA, NA)	0.52 (0.5, 0.6)	0.53 (0.51, 0.58)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.067 (0.042, 0.101)	0.067 (0, 0.123)	0 (0, 0.88)	0 (0, 0.097)					0 (0, 0)	NA (NA, NA)	0 (0, 0.053)	0 (0, 0.419)
AR- & TP53-	TC2	count	59	59	59	59					59	59	59	59
AR- & TP53-	TC2	time	10 (8, 19)	10 (8, 19)	10 (8, 19)	10 (8, 19)					10 (8, 19)	10 (8, 19)	10 (8, 19)	10 (8, 19)
AR- & TP53-	TC2	n	23 (18, 36)	3 (1, 5)	1 (0, 3)	1 (0, 4)					3 (1, 7)	0 (0, 0)	1 (0, 3)	0 (0, 2)
AR- & TP53-	TC2	post_p	0.85 (0.72, 0.91)	0.59 (0.51, 0.75)	0.55 (0.52, 0.64)	0.59 (0.53, 0.77)					0.62 (0.52, 0.75)	NA (NA, NA)	0.57 (0.52, 0.8)	0.54 (0.51, 0.64)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.074 (0.053, 0.094)	0.05 (0, 0.111)	0 (0, 0.07)	0 (0, 0.058)					0.036 (0, 0.102)	NA (NA, NA)	0 (0, 0.065)	0 (0, 0.07)
AR- & TP53-	TC3	count	8	8	8	8					8	8	8	8
AR- & TP53-	TC3	time	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)					10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)
AR- & TP53-	TC3	n	14 (11, 21)	4 (2, 4)	0 (0, 1)	0 (0, 3)					7 (4, 8)	0 (0, 0)	1 (0, 4)	1 (0, 2)
AR- & TP53-	TC3	post_p	0.79 (0.77, 0.9)	0.54 (0.52, 0.62)	0.54 (0.51, 0.6)	0.55 (0.54, 0.56)					0.72 (0.6, 0.77)	NA (NA, NA)	0.55 (0.53, 0.66)	0.57 (0.57, 0.57)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.055 (0.016, 0.069)	0.038 (0, 0.087)	0 (0, 0)	0 (0, 0)					0.057 (0, 0.095)	1.603 (1.603, 1.603)	0.024 (0, 0.241)	0 (0, 0.065)
AR- & TP53-	TC4	count	7	7	7	7					7	7	7	7
AR- & TP53-	TC4	time	11 (9, 16)	11 (9, 16)	11 (9, 16)	11 (9, 16)					11 (9, 16)	11 (9, 16)	11 (9, 16)	11 (9, 16)
AR- & TP53-	TC4	n	13 (12, 26)	3 (1, 6)	0 (0, 0)	3 (1, 4)					5 (4, 11)	0 (0, 0)	2 (1, 6)	2 (1, 3)
AR- & TP53-	TC4	post_p	0.83 (0.76, 0.93)	0.58 (0.53, 0.75)	0.54 (0.54, 0.54)	0.56 (0.51, 0.6)					0.59 (0.56, 0.83)	NA (NA, NA)	0.57 (0.55, 0.69)	0.54 (0.52, 0.57)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.058 (0.054, 0.072)	0 (0, 0.127)	0 (0, 0)	0 (0, 0.104)					0.059 (0.04, 0.093)	NA (NA, NA)	0.084 (0, 0.272)	0.119 (0, 0.868)
AR- & TP53-	TC5	count	5	5	5	5					5	5	5	5
AR- & TP53-	TC5	time	13 (10, 17)	13 (10, 17)	13 (10, 17)	13 (10, 17)					13 (10, 17)	13 (10, 17)	13 (10, 17)	13 (10, 17)
AR- & TP53-	TC5	n	25 (15, 29)	10 (3, 12)	1 (0, 4)	3 (2, 5)					2 (1, 4)	0 (0, 0)	1 (1, 2)	1 (0, 1)
AR- & TP53-	TC5	post_p	0.9 (0.76, 0.92)	0.72 (0.59, 0.74)	0.52 (0.5, 0.57)	0.56 (0.52, 0.61)					0.58 (0.54, 0.71)	NA (NA, NA)	0.58 (0.56, 0.63)	0.55 (0.55, 0.55)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.066 (0.062, 0.071)	0.075 (0.049, 0.106)	0.033 (0, 0.114)	0.033 (0.012, 0.129)					0 (0, 0.08)	NA (NA, NA)	0 (0, 0)	0.586 (0.117, 0.738)
HRD+	TC1	count									1	1	1	1	1	1	1	1									1	1	1	1	1	1	1	1
HRD+	TC1	time									23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)									23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)	23 (23, 23)
HRD+	TC1	n									18 (18, 18)	0 (0, 0)	2 (2, 2)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)									1 (1, 1)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.98 (0.98, 0.98)	NA (NA, NA)	0.51 (0.51, 0.51)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.57 (0.57, 0.57)									0.58 (0.58, 0.58)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.069 (0.069, 0.069)	NA (NA, NA)	0.15 (0.15, 0.15)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)									0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									36	36	36	36	36	36	36	36									36	36	36	36	36	36	36	36
HRD+	TC2	time									29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)									29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)
HRD+	TC2	n									14 (6, 18)	0 (0, 0)	5 (2, 10)	2 (0, 6)	0 (0, 0)	0 (0, 4)	0 (0, 0)	1 (0, 3)									4 (1, 8)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.79 (0.71, 0.93)	NA (NA, NA)	0.83 (0.52, 0.96)	0.61 (0.55, 0.87)	NA (NA, NA)	0.55 (0.51, 0.85)	NA (NA, NA)	0.6 (0.52, 0.78)									0.7 (0.54, 0.87)	NA (NA, NA)	0.57 (0.53, 0.67)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.082 (0.064, 0.109)	NA (NA, NA)	0.034 (0, 0.077)	0.03 (0, 0.065)	NA (NA, NA)	0.063 (0, 0.128)	0.481 (0.196, 0.767)	0.034 (0, 0.098)									0.058 (0, 0.135)	NA (NA, NA)	0 (0, 0.082)	NA (NA, NA)	11.816 (2.363, 21.269)	NA (NA, NA)	0.089 (0.018, 0.159)	0 (0, 0)
HRD+	TC3	count									7	7	7	7	7	7	7	7									7	7	7	7	7	7	7	7
HRD+	TC3	time									21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)									21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)	21 (19, 30)
HRD+	TC3	n									14 (13, 23)	0 (0, 0)	4 (4, 5)	2 (0, 3)	0 (0, 0)	1 (0, 2)	0 (0, 0)	2 (1, 2)									2 (1, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)
HRD+	TC3	post_p									0.88 (0.75, 0.95)	NA (NA, NA)	0.56 (0.53, 0.68)	0.57 (0.52, 0.7)	NA (NA, NA)	0.61 (0.54, 0.66)	NA (NA, NA)	0.53 (0.52, 0.57)									0.75 (0.61, 0.8)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.082 (0.061, 0.103)	NA (NA, NA)	0.084 (0.059, 0.13)	0.05 (0.01, 0.125)	NA (NA, NA)	0.036 (0, 0.54)	NA (NA, NA)	0.051 (0, 0.166)									0.068 (0, 0.085)	NA (NA, NA)	0.073 (0.062, 0.148)	NA (NA, NA)	0.101 (0.02, 0.181)	NA (NA, NA)	0.285 (0.285, 0.285)	0.247 (0.049, 0.445)
HRD+	TC4	count									5	5	5	5	5	5	5	5									5	5	5	5	5	5	5	5
HRD+	TC4	time									20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)									20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)	20 (19, 25)
HRD+	TC4	n									12 (10, 21)	0 (0, 0)	5 (3, 8)	2 (1, 3)	0 (0, 0)	0 (0, 6)	0 (0, 0)	1 (0, 3)									4 (1, 10)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
HRD+	TC4	post_p									0.91 (0.75, 0.95)	NA (NA, NA)	0.73 (0.54, 0.82)	0.65 (0.59, 0.67)	NA (NA, NA)	0.71 (0.69, 0.73)	NA (NA, NA)	0.55 (0.53, 0.58)									0.69 (0.58, 0.78)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.085 (0.047, 0.098)	NA (NA, NA)	0.09 (0.063, 0.103)	0.108 (0.015, 0.329)	NA (NA, NA)	0.074 (0.053, 0.095)	NA (NA, NA)	0 (0, 0.129)									0.078 (0.071, 0.097)	NA (NA, NA)	0.078 (0.062, 0.18)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
HRD+	TC5	count									6	6	6	6	6	6	6	6									6	6	6	6	6	6	6	6
HRD+	TC5	time									26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)									26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)
HRD+	TC5	n									12 (11, 16)	0 (0, 0)	6 (4, 8)	0 (0, 4)	0 (0, 0)	0 (0, 2)	0 (0, 0)	1 (0, 2)									5 (2, 6)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.81 (0.74, 0.88)	NA (NA, NA)	0.68 (0.57, 0.78)	0.64 (0.61, 0.69)	NA (NA, NA)	0.6 (0.57, 0.63)	NA (NA, NA)	0.58 (0.52, 0.64)									0.67 (0.53, 0.76)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.066 (0.062, 0.093)	NA (NA, NA)	0.064 (0.047, 0.084)	0 (0, 0.036)	NA (NA, NA)	0 (0, 0.039)	NA (NA, NA)	0.048 (0, 0.104)									0.081 (0.035, 0.126)	NA (NA, NA)	0.136 (0.037, 0.188)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
TP53+	TC2	count					60	60	60	60					60	60	60	60					60	60	60	60					60	60	60	60
TP53+	TC2	time					15 (11, 28)	15 (11, 28)	15 (11, 28)	15 (11, 28)					15 (11, 28)	15 (11, 28)	15 (11, 28)	15 (11, 28)					15 (11, 28)	15 (11, 28)	15 (11, 28)	15 (11, 28)					15 (11, 28)	15 (11, 28)	15 (11, 28)	15 (11, 28)
TP53+	TC2	n					5 (3, 14)	4 (2, 10)	2 (1, 5)	4 (3, 11)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 2)	0 (0, 0)	8 (5, 13)	4 (2, 10)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.71 (0.55, 0.85)	0.7 (0.54, 0.84)	0.6 (0.53, 0.75)	0.73 (0.59, 0.91)					NA (NA, NA)	0.55 (0.54, 0.6)	NA (NA, NA)	0.55 (0.52, 0.62)					0.53 (0.52, 0.58)	NA (NA, NA)	0.75 (0.61, 0.94)	0.74 (0.55, 0.94)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.074 (0.032, 0.132)	0.069 (0.011, 0.118)	0.023 (0, 0.06)	0.03 (0, 0.06)					NA (NA, NA)	0 (0, 0.115)	NA (NA, NA)	0 (0, 0.152)					0.056 (0, 0.28)	0 (0, 0)	0.034 (0, 0.06)	0.027 (0, 0.069)					0 (0, 0)	0.179 (0.179, 0.179)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					2	2	2	2					2	2	2	2					2	2	2	2					2	2	2	2
TP53+	TC3	time					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)
TP53+	TC3	n					7 (5, 9)	6 (3, 8)	2 (1, 4)	2 (2, 3)					0 (0, 0)	0 (0, 1)	0 (0, 0)	2 (0, 4)					0 (0, 0)	0 (0, 0)	4 (3, 4)	2 (0, 4)					2 (0, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.81 (0.73, 0.9)	0.78 (0.68, 0.88)	0.54 (0.53, 0.55)	0.59 (0.55, 0.63)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)					NA (NA, NA)	NA (NA, NA)	0.6 (0.59, 0.61)	0.5 (0.5, 0.5)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.017 (0.003, 0.031)	0.041 (0.023, 0.058)	0.034 (0.007, 0.062)	0.028 (0.006, 0.05)					NA (NA, NA)	0.163 (0.163, 0.163)	NA (NA, NA)	0.07 (0.07, 0.07)					NA (NA, NA)	NA (NA, NA)	0.076 (0.064, 0.087)	0.072 (0.072, 0.072)					0.181 (0.181, 0.181)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	count					2	2	2	2					2	2	2	2					2	2	2	2					2	2	2	2
TP53+	TC5	time					11 (10, 12)	11 (10, 12)	11 (10, 12)	11 (10, 12)					11 (10, 12)	11 (10, 12)	11 (10, 12)	11 (10, 12)					11 (10, 12)	11 (10, 12)	11 (10, 12)	11 (10, 12)					11 (10, 12)	11 (10, 12)	11 (10, 12)	11 (10, 12)
TP53+	TC5	n					2 (1, 4)	8 (6, 10)	0 (0, 1)	5 (3, 7)					0 (0, 0)	2 (1, 2)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	5 (3, 7)	4 (3, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.54 (0.52, 0.55)	0.81 (0.71, 0.9)	0.52 (0.52, 0.52)	0.67 (0.6, 0.75)					NA (NA, NA)	0.59 (0.56, 0.62)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.68 (0.61, 0.75)	0.51 (0.51, 0.51)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.026 (0.005, 0.047)	0.03 (0.006, 0.054)	0 (0, 0)	0.069 (0.06, 0.078)					NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.084 (0.074, 0.095)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			228	228			228	228			228	228			228	228			228	228			228	228			228	228			228	228
TEfus+	TC2	time			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)
TEfus+	TC2	n			2 (0, 4)	3 (1, 10)			3 (1, 7)	6 (2, 15)			3 (0, 8)	1 (0, 4)			0 (0, 0)	1 (0, 3)			3 (1, 7)	1 (0, 3)			10 (5, 18)	5 (2, 13)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.6 (0.52, 0.81)	0.7 (0.53, 0.92)			0.62 (0.52, 0.83)	0.77 (0.57, 0.97)			0.67 (0.54, 0.91)	0.59 (0.52, 0.8)			NA (NA, NA)	0.57 (0.51, 0.66)			0.65 (0.54, 0.89)	0.58 (0.51, 0.73)			0.78 (0.65, 0.97)	0.77 (0.55, 0.96)			0.58 (0.52, 0.64)	NA (NA, NA)			NA (NA, NA)	0.55 (0.55, 0.55)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0 (0, 0.09)	0.02 (0, 0.081)			0.023 (0, 0.072)	0.029 (0, 0.067)			0.013 (0, 0.08)	0 (0, 0.088)			0.419 (0.084, 0.755)	0 (0, 0.128)			0.026 (0, 0.077)	0 (0, 0.09)			0.033 (0, 0.064)	0.032 (0, 0.072)			0 (0, 0.083)	0 (0, 1.494)			1.249 (0.391, 2.107)	0 (0, 0.281)
PI3K+	TC2	count		63		63		63		63		63		63		63		63		63		63		63		63		63		63		63		63
PI3K+	TC2	time		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)		20 (13, 28)
PI3K+	TC2	n		6 (2, 16)		3 (1, 9)		6 (3, 12)		6 (2, 13)		0 (0, 0)		1 (0, 4)		1 (0, 2)		0 (0, 2)		1 (0, 2)		1 (0, 4)		0 (0, 0)		5 (2, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.72 (0.53, 0.89)		0.7 (0.56, 0.89)		0.73 (0.54, 0.87)		0.8 (0.62, 0.96)		NA (NA, NA)		0.61 (0.54, 0.69)		0.56 (0.51, 0.67)		0.6 (0.52, 0.74)		0.57 (0.5, 0.72)		0.56 (0.51, 0.72)		NA (NA, NA)		0.74 (0.58, 0.94)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.078 (0.031, 0.114)		0.027 (0, 0.06)		0.073 (0.002, 0.12)		0.035 (0, 0.053)		0.133 (0.133, 0.133)		0 (0, 0.064)		0.047 (0, 0.262)		0 (0, 0.116)		0.11 (0, 0.739)		0.022 (0, 0.096)		0.244 (0.109, 0.379)		0.038 (0, 0.071)		0 (0, 0)		0 (0, 0)		NA (NA, NA)		0.176 (0.035, 0.316)
PI3K+	TC3	count		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1
PI3K+	TC3	time		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)
PI3K+	TC3	n		5 (5, 5)		3 (3, 3)		10 (10, 10)		2 (2, 2)		0 (0, 0)		2 (2, 2)		0 (0, 0)		0 (0, 0)		2 (2, 2)		2 (2, 2)		0 (0, 0)		2 (2, 2)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.73 (0.73, 0.73)		0.65 (0.65, 0.65)		0.89 (0.89, 0.89)		0.55 (0.55, 0.55)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.59 (0.59, 0.59)		0.52 (0.52, 0.52)		NA (NA, NA)		0.66 (0.66, 0.66)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.042 (0.042, 0.042)		0 (0, 0)		0.021 (0.021, 0.021)		0.062 (0.062, 0.062)		NA (NA, NA)		0.171 (0.171, 0.171)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)		0.115 (0.115, 0.115)		NA (NA, NA)		0.082 (0.082, 0.082)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	count		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4		4
PI3K+	TC5	time		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)		14 (10, 14)
PI3K+	TC5	n		10 (6, 12)		4 (4, 4)		4 (3, 9)		4 (3, 5)		0 (0, 0)		0 (0, 0)		1 (0, 2)		0 (0, 0)		0 (0, 1)		1 (0, 3)		0 (0, 1)		3 (2, 4)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.75 (0.62, 0.83)		0.54 (0.51, 0.57)		0.64 (0.53, 0.86)		0.57 (0.51, 0.77)		NA (NA, NA)		NA (NA, NA)		0.64 (0.59, 0.68)		NA (NA, NA)		NA (NA, NA)		0.53 (0.53, 0.53)		NA (NA, NA)		0.56 (0.52, 0.61)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.038 (0.03, 0.091)		0.073 (0.048, 0.112)		0.066 (0.052, 0.129)		0.083 (0.054, 0.132)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)		0.22 (0.22, 0.22)		0.043 (0.009, 0.196)		0 (0, 0)		0.025 (0, 0.058)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13
all	TC1	time	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)	4 (3, 11)
all	TC1	n	17 (14, 23)	3 (1, 5)	0 (0, 3)	1 (0, 2)	2 (1, 4)	1 (0, 4)	0 (0, 1)	0 (0, 4)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	1 (0, 3)	0 (0, 3)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.31 (0.09, 0.44)	0.41 (0.34, 0.47)	0.48 (0.48, 0.49)	0.41 (0.29, 0.44)	0.45 (0.39, 0.48)	0.42 (0.33, 0.47)	0.41 (0.35, 0.48)	0.46 (0.3, 0.5)	0.3 (0.28, 0.32)	NA (NA, NA)	0.5 (0.5, 0.5)	0.36 (0.36, 0.36)	NA (NA, NA)	0.45 (0.45, 0.45)	NA (NA, NA)	0.45 (0.45, 0.45)	0.44 (0.41, 0.47)	0.43 (0.42, 0.44)	0.39 (0.31, 0.47)	0.46 (0.43, 0.48)	0.42 (0.42, 0.42)	NA (NA, NA)	0.43 (0.31, 0.46)	0.39 (0.34, 0.44)	0.31 (0.31, 0.31)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.152 (0.096, 0.197)	0.161 (0.012, 0.262)	0.155 (0.036, 0.39)	0.312 (0.104, 10.848)	0.222 (0.012, 0.462)	0.153 (0.05, 2.087)	0 (0, 1.014)	0.116 (0, 0.336)	0.231 (0.176, 0.429)	NA (NA, NA)	0.04 (0.008, 0.071)	0.497 (0.497, 0.497)	NA (NA, NA)	0.205 (0.041, 0.369)	NA (NA, NA)	0.178 (0.178, 0.178)	0.205 (0, 0.857)	0.909 (0.418, 1)	0 (0, 0.163)	0 (0, 0.463)	0.117 (0.023, 1.04)	NA (NA, NA)	0.224 (0.08, 1.308)	0.349 (0.047, 0.486)	0.192 (0.15, 0.234)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC3	time	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)	22 (13, 28)
all	TC3	n	10 (7, 17)	6 (2, 11)	1 (0, 2)	2 (1, 4)	5 (2, 6)	4 (3, 4)	2 (0, 3)	5 (2, 6)	4 (3, 8)	0 (0, 1)	2 (0, 8)	3 (1, 5)	0 (0, 0)	1 (0, 1)	0 (0, 0)	2 (0, 3)	2 (0, 4)	0 (0, 0)	2 (0, 3)	0 (0, 1)	0 (0, 1)	0 (0, 0)	3 (2, 5)	1 (0, 4)	2 (1, 5)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)
all	TC3	post_p	0.38 (0.22, 0.4)	0.3 (0.16, 0.43)	0.4 (0.33, 0.4)	0.39 (0.32, 0.46)	0.32 (0.16, 0.37)	0.41 (0.32, 0.49)	0.42 (0.37, 0.47)	0.43 (0.37, 0.49)	0.33 (0.23, 0.45)	NA (NA, NA)	0.44 (0.43, 0.46)	0.39 (0.27, 0.43)	NA (NA, NA)	0.46 (0.45, 0.48)	NA (NA, NA)	0.45 (0.45, 0.45)	0.4 (0.22, 0.46)	NA (NA, NA)	0.38 (0.34, 0.48)	0.4 (0.4, 0.4)	0.45 (0.45, 0.45)	NA (NA, NA)	0.42 (0.26, 0.46)	0.39 (0.26, 0.4)	0.37 (0.36, 0.45)	NA (NA, NA)	0.44 (0.44, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.142 (0.134, 0.168)	0.258 (0.161, 0.357)	0.305 (0.127, 0.401)	0.166 (0.113, 0.354)	0.142 (0.104, 0.261)	0.177 (0.13, 0.229)	0.229 (0.129, 0.836)	0.134 (0.1, 0.461)	0.293 (0.134, 0.407)	0.122 (0.122, 0.122)	0.215 (0.112, 0.217)	0.156 (0.092, 0.349)	NA (NA, NA)	0.909 (0.182, 10.6)	NA (NA, NA)	0.135 (0.118, 0.317)	0.355 (0.149, 0.625)	NA (NA, NA)	0.136 (0.084, 0.412)	0.099 (0.099, 0.099)	2.377 (2.377, 2.377)	NA (NA, NA)	0.151 (0.144, 0.208)	0.28 (0.17, 5.538)	0.163 (0.141, 0.206)	NA (NA, NA)	0.9 (0.307, 1.493)	0.311 (0.311, 0.311)	NA (NA, NA)	NA (NA, NA)	0.609 (0.609, 0.609)	NA (NA, NA)
all	TC5	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC5	time	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)	22 (12, 25)
all	TC5	n	15 (5, 47)	5 (3, 10)	0 (0, 3)	5 (1, 10)	4 (2, 6)	4 (2, 6)	1 (0, 5)	5 (4, 8)	4 (1, 10)	0 (0, 0)	2 (0, 4)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	1 (0, 3)	0 (0, 0)	1 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	5 (3, 7)	4 (3, 7)	1 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.31 (0.14, 0.35)	0.34 (0.13, 0.38)	0.29 (0.19, 0.39)	0.4 (0.27, 0.45)	0.44 (0.24, 0.45)	0.26 (0.21, 0.29)	0.4 (0.31, 0.42)	0.16 (0.11, 0.2)	0.36 (0.23, 0.4)	NA (NA, NA)	0.31 (0.27, 0.39)	0.5 (0.49, 0.5)	NA (NA, NA)	0.4 (0.4, 0.4)	NA (NA, NA)	0.39 (0.39, 0.39)	0.49 (0.48, 0.49)	NA (NA, NA)	0.36 (0.27, 0.46)	NA (NA, NA)	0.4 (0.4, 0.4)	NA (NA, NA)	0.28 (0.19, 0.3)	0.39 (0.37, 0.47)	0.42 (0.39, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.144 (0.119, 0.294)	0.158 (0.121, 0.543)	0.31 (0.178, 0.443)	0.147 (0.098, 0.267)	0.164 (0.128, 0.438)	0.205 (0.169, 0.767)	1.415 (0.127, 6.038)	0.182 (0.072, 0.287)	0.152 (0.119, 0.233)	NA (NA, NA)	0.206 (0.134, 0.295)	0.037 (0.007, 0.066)	NA (NA, NA)	0.229 (0.229, 0.229)	NA (NA, NA)	0.291 (0.131, 0.452)	0.099 (0.076, 0.652)	NA (NA, NA)	0.128 (0.091, 0.386)	0.308 (0.062, 0.554)	0.361 (0.361, 0.361)	NA (NA, NA)	0.141 (0.048, 0.163)	0.156 (0.094, 0.502)	0.098 (0.02, 0.209)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.775 (0.775, 0.775)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	125	125	125	125					125	125	125	125
AR- & TP53-	TC1	time	13 (6, 30)	13 (6, 30)	13 (6, 30)	13 (6, 30)					13 (6, 30)	13 (6, 30)	13 (6, 30)	13 (6, 30)
AR- & TP53-	TC1	n	24 (16, 46)	5 (2, 11)	1 (0, 4)	3 (0, 6)					3 (0, 9)	0 (0, 0)	1 (0, 5)	1 (0, 2)
AR- & TP53-	TC1	post_p	0.32 (0.11, 0.45)	0.38 (0.19, 0.48)	0.44 (0.31, 0.49)	0.41 (0.29, 0.47)					0.42 (0.17, 0.49)	NA (NA, NA)	0.42 (0.27, 0.49)	0.42 (0.32, 0.49)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.126 (0.102, 0.172)	0.153 (0.102, 0.44)	0.172 (0, 0.798)	0.145 (0.092, 0.494)					0.172 (0.096, 0.656)	0.463 (0.463, 0.463)	0.159 (0.075, 0.858)	0.21 (0, 1.105)
AR- & TP53-	TC2	count	8	8	8	8					8	8	8	8
AR- & TP53-	TC2	time	12 (9, 18)	12 (9, 18)	12 (9, 18)	12 (9, 18)					12 (9, 18)	12 (9, 18)	12 (9, 18)	12 (9, 18)
AR- & TP53-	TC2	n	15 (10, 29)	4 (2, 7)	0 (0, 2)	1 (0, 2)					4 (4, 5)	0 (0, 0)	1 (0, 3)	1 (0, 1)
AR- & TP53-	TC2	post_p	0.29 (0.08, 0.46)	0.4 (0.11, 0.46)	0.44 (0.41, 0.48)	0.44 (0.4, 0.48)					0.48 (0.37, 0.5)	NA (NA, NA)	0.46 (0.4, 0.48)	0.39 (0.31, 0.45)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.146 (0.112, 0.189)	0.215 (0.106, 0.309)	0.104 (0.031, 0.115)	0.111 (0.036, 0.612)					0.147 (0.114, 0.225)	NA (NA, NA)	0.157 (0.04, 0.263)	0.11 (0, 0.565)
AR- & TP53-	TC3	count	121	121	121	121					121	121	121	121
AR- & TP53-	TC3	time	21 (13, 33)	21 (13, 33)	21 (13, 33)	21 (13, 33)					21 (13, 33)	21 (13, 33)	21 (13, 33)	21 (13, 33)
AR- & TP53-	TC3	n	20 (8, 52)	6 (3, 13)	1 (0, 3)	3 (1, 8)					7 (3, 13)	0 (0, 0)	4 (1, 9)	2 (0, 4)
AR- & TP53-	TC3	post_p	0.31 (0.09, 0.46)	0.38 (0.17, 0.48)	0.42 (0.3, 0.49)	0.4 (0.22, 0.49)					0.37 (0.18, 0.48)	NA (NA, NA)	0.37 (0.16, 0.49)	0.41 (0.31, 0.48)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.135 (0.109, 0.228)	0.158 (0.114, 0.345)	0.174 (0.076, 0.526)	0.156 (0.084, 0.566)					0.153 (0.11, 0.303)	0 (0, 0)	0.143 (0.076, 0.482)	0.172 (0.085, 0.473)
AR- & TP53-	TC4	count	124	124	124	124					124	124	124	124
AR- & TP53-	TC4	time	22 (13, 31)	22 (13, 31)	22 (13, 31)	22 (13, 31)					22 (13, 31)	22 (13, 31)	22 (13, 31)	22 (13, 31)
AR- & TP53-	TC4	n	21 (8, 52)	6 (2, 12)	1 (0, 3)	3 (1, 8)					7 (3, 12)	0 (0, 0)	4 (2, 8)	2 (1, 5)
AR- & TP53-	TC4	post_p	0.32 (0.1, 0.48)	0.34 (0.17, 0.47)	0.42 (0.31, 0.49)	0.38 (0.21, 0.48)					0.35 (0.19, 0.47)	NA (NA, NA)	0.38 (0.22, 0.48)	0.42 (0.28, 0.49)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.134 (0.107, 0.192)	0.162 (0.105, 0.404)	0.176 (0.063, 0.721)	0.178 (0.081, 0.59)					0.15 (0.104, 0.31)	0.134 (0.027, 0.545)	0.146 (0.08, 0.375)	0.147 (0.065, 0.489)
AR- & TP53-	TC5	count	100	100	100	100					100	100	100	100
AR- & TP53-	TC5	time	21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)					21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)
AR- & TP53-	TC5	n	17 (7, 41)	8 (4, 16)	1 (0, 3)	4 (2, 7)					4 (2, 11)	0 (0, 0)	3 (0, 7)	1 (0, 3)
AR- & TP53-	TC5	post_p	0.33 (0.1, 0.46)	0.32 (0.18, 0.47)	0.42 (0.26, 0.48)	0.37 (0.22, 0.46)					0.36 (0.21, 0.48)	NA (NA, NA)	0.38 (0.2, 0.49)	0.44 (0.32, 0.49)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.132 (0.109, 0.224)	0.148 (0.101, 0.269)	0.19 (0.059, 0.636)	0.141 (0.092, 0.312)					0.175 (0.11, 0.406)	7.972 (7.972, 7.972)	0.159 (0.084, 0.451)	0.14 (0.067, 0.623)
HRD+	TC1	count									23	23	23	23	23	23	23	23									23	23	23	23	23	23	23	23
HRD+	TC1	time									32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)									32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)
HRD+	TC1	n									11 (5, 18)	0 (0, 1)	5 (3, 9)	2 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 2)									4 (2, 8)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.38 (0.21, 0.49)	NA (NA, NA)	0.34 (0.18, 0.47)	0.4 (0.22, 0.49)	NA (NA, NA)	0.38 (0.29, 0.45)	NA (NA, NA)	0.42 (0.3, 0.48)									0.42 (0.23, 0.48)	NA (NA, NA)	0.46 (0.4, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.131 (0.104, 0.236)	0.091 (0.064, 1.086)	0.121 (0.089, 0.31)	0.161 (0.082, 0.499)	0 (0, 0)	0.426 (0.169, 1.056)	NA (NA, NA)	0.186 (0.093, 0.53)									0.145 (0.108, 0.384)	NA (NA, NA)	0.041 (0, 0.222)	0.279 (0.279, 0.279)	0.214 (0.043, 0.486)	0.316 (0.316, 0.316)	NA (NA, NA)	0.207 (0.207, 0.207)
HRD+	TC3	count									41	41	41	41	41	41	41	41									41	41	41	41	41	41	41	41
HRD+	TC3	time									29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)									29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)	29 (24, 35)
HRD+	TC3	n									12 (5, 20)	0 (0, 0)	6 (3, 12)	2 (0, 5)	0 (0, 0)	1 (0, 4)	0 (0, 0)	2 (0, 4)									4 (2, 6)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.4 (0.23, 0.49)	NA (NA, NA)	0.33 (0.16, 0.46)	0.39 (0.32, 0.47)	NA (NA, NA)	0.44 (0.35, 0.48)	NA (NA, NA)	0.41 (0.31, 0.48)									0.38 (0.25, 0.48)	NA (NA, NA)	0.42 (0.37, 0.46)	NA (NA, NA)	0.45 (0.45, 0.45)	NA (NA, NA)	0.38 (0.38, 0.38)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.135 (0.104, 0.25)	0.122 (0.122, 0.122)	0.123 (0.084, 0.222)	0.141 (0.083, 0.389)	0 (0, 0)	0.164 (0.091, 0.552)	NA (NA, NA)	0.145 (0.086, 0.286)									0.148 (0.104, 0.279)	0.239 (0.239, 0.239)	0.21 (0.074, 0.656)	0.104 (0.104, 0.104)	0.09 (0, 1.623)	0.095 (0.065, 0.676)	0.262 (0.262, 0.262)	0 (0, 1.086)
HRD+	TC4	count									52	52	52	52	52	52	52	52									52	52	52	52	52	52	52	52
HRD+	TC4	time									29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)									29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)	29 (21, 36)
HRD+	TC4	n									11 (5, 17)	0 (0, 0)	5 (2, 10)	2 (1, 5)	0 (0, 0)	2 (0, 4)	0 (0, 0)	2 (0, 4)									4 (2, 6)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.37 (0.11, 0.47)	NA (NA, NA)	0.36 (0.2, 0.45)	0.43 (0.26, 0.48)	0.49 (0.49, 0.49)	0.42 (0.31, 0.48)	NA (NA, NA)	0.41 (0.26, 0.48)									0.38 (0.25, 0.47)	NA (NA, NA)	0.46 (0.4, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.131 (0.102, 0.285)	0.648 (0.648, 0.648)	0.126 (0.08, 0.287)	0.171 (0.074, 0.42)	0.052 (0, 0.122)	0.162 (0.071, 0.417)	NA (NA, NA)	0.169 (0.07, 0.807)									0.175 (0.094, 0.439)	0.676 (0.135, 1.217)	0.107 (0, 0.812)	0.072 (0.07, 1.738)	0 (0, 0)	0.072 (0.014, 0.129)	0.268 (0.268, 0.268)	NA (NA, NA)
HRD+	TC5	count									28	28	28	28	28	28	28	28									28	28	28	28	28	28	28	28
HRD+	TC5	time									30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)									30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)	30 (26, 35)
HRD+	TC5	n									14 (7, 19)	0 (0, 0)	4 (2, 9)	2 (0, 4)	0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 3)									4 (1, 8)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.37 (0.19, 0.48)	NA (NA, NA)	0.33 (0.18, 0.46)	0.38 (0.23, 0.48)	NA (NA, NA)	0.43 (0.32, 0.48)	NA (NA, NA)	0.4 (0.3, 0.45)									0.33 (0.23, 0.48)	NA (NA, NA)	0.41 (0.36, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.127 (0.106, 0.177)	7.769 (7.769, 7.769)	0.17 (0.094, 0.603)	0.181 (0.074, 0.431)	NA (NA, NA)	0.246 (0.063, 3.778)	10.851 (10.851, 10.851)	0.212 (0.095, 0.389)									0.21 (0.113, 0.431)	0.195 (0.195, 0.195)	0.211 (0.085, 1.007)	NA (NA, NA)	0.414 (0.274, 0.555)	0.065 (0.065, 0.065)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					100	100	100	100					100	100	100	100					100	100	100	100					100	100	100	100
TP53+	TC1	time					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)
TP53+	TC1	n					8 (4, 16)	6 (3, 13)	3 (1, 5)	5 (2, 11)					0 (0, 0)	0 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	5 (3, 10)	4 (1, 7)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.34 (0.12, 0.49)	0.35 (0.17, 0.48)	0.41 (0.25, 0.48)	0.35 (0.17, 0.48)					NA (NA, NA)	0.43 (0.37, 0.48)	NA (NA, NA)	0.42 (0.32, 0.49)					0.46 (0.4, 0.48)	NA (NA, NA)	0.31 (0.13, 0.45)	0.35 (0.17, 0.46)					0.49 (0.43, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.144 (0.103, 0.271)	0.158 (0.109, 0.298)	0.16 (0.073, 0.603)	0.141 (0.09, 0.313)					NA (NA, NA)	0.204 (0.088, 0.764)	0.079 (0.079, 0.079)	0.209 (0, 0.666)					0.21 (0, 0.336)	0.199 (0.043, 0.375)	0.133 (0.085, 0.274)	0.158 (0.091, 0.327)					0.281 (0, 6.122)	0 (0, 0)	1.644 (1.644, 1.644)	0 (0, 0)
TP53+	TC3	count					87	87	87	87					87	87	87	87					87	87	87	87					87	87	87	87
TP53+	TC3	time					25 (17, 34)	25 (17, 34)	25 (17, 34)	25 (17, 34)					25 (17, 34)	25 (17, 34)	25 (17, 34)	25 (17, 34)					25 (17, 34)	25 (17, 34)	25 (17, 34)	25 (17, 34)					25 (17, 34)	25 (17, 34)	25 (17, 34)	25 (17, 34)
TP53+	TC3	n					5 (3, 11)	5 (2, 11)	2 (0, 4)	4 (2, 10)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	4 (2, 8)	4 (2, 7)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.31 (0.15, 0.47)	0.35 (0.19, 0.48)	0.39 (0.23, 0.47)	0.32 (0.16, 0.46)					NA (NA, NA)	0.43 (0.35, 0.48)	NA (NA, NA)	0.42 (0.34, 0.48)					0.45 (0.39, 0.49)	NA (NA, NA)	0.33 (0.14, 0.47)	0.35 (0.18, 0.48)					0.44 (0.42, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.17 (0.111, 0.469)	0.166 (0.117, 0.329)	0.2 (0.078, 0.579)	0.141 (0.09, 0.392)					0.126 (0.025, 0.128)	0.174 (0.073, 0.886)	0 (0, 0)	0.199 (0.093, 0.759)					0.212 (0, 0.794)	0.138 (0.108, 0.21)	0.139 (0.085, 0.274)	0.148 (0.09, 0.313)					0.126 (0.004, 1.162)	0.1 (0, 0.433)	0.121 (0.017, 0.565)	0.047 (0, 0.848)
TP53+	TC4	count					77	77	77	77					77	77	77	77					77	77	77	77					77	77	77	77
TP53+	TC4	time					27 (17, 34)	27 (17, 34)	27 (17, 34)	27 (17, 34)					27 (17, 34)	27 (17, 34)	27 (17, 34)	27 (17, 34)					27 (17, 34)	27 (17, 34)	27 (17, 34)	27 (17, 34)					27 (17, 34)	27 (17, 34)	27 (17, 34)	27 (17, 34)
TP53+	TC4	n					6 (3, 11)	5 (3, 12)	2 (0, 5)	4 (2, 14)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					1 (0, 2)	0 (0, 0)	6 (3, 11)	5 (2, 8)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.3 (0.1, 0.46)	0.35 (0.17, 0.46)	0.42 (0.31, 0.49)	0.35 (0.16, 0.46)					NA (NA, NA)	0.44 (0.34, 0.49)	NA (NA, NA)	0.42 (0.31, 0.47)					0.45 (0.37, 0.48)	NA (NA, NA)	0.3 (0.16, 0.47)	0.36 (0.18, 0.47)					NA (NA, NA)	0.5 (0.5, 0.5)	0.47 (0.47, 0.47)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.171 (0.113, 0.462)	0.16 (0.119, 0.335)	0.143 (0.079, 0.354)	0.149 (0.085, 0.389)					0.124 (0.124, 0.124)	0.184 (0, 0.645)	0.098 (0.02, 0.177)	0.251 (0.089, 0.865)					0.167 (0, 0.424)	0 (0, 0)	0.136 (0.083, 0.355)	0.146 (0.086, 0.266)					0.101 (0, 0.182)	0.348 (0.184, 0.512)	0.109 (0.022, 0.196)	NA (NA, NA)
TP53+	TC5	count					109	109	109	109					109	109	109	109					109	109	109	109					109	109	109	109
TP53+	TC5	time					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)
TP53+	TC5	n					5 (3, 11)	7 (4, 13)	2 (0, 5)	6 (3, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 2)	0 (0, 0)	5 (2, 9)	5 (2, 8)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.35 (0.17, 0.46)	0.34 (0.15, 0.48)	0.41 (0.29, 0.48)	0.3 (0.13, 0.47)					NA (NA, NA)	0.44 (0.37, 0.5)	NA (NA, NA)	0.44 (0.34, 0.48)					0.46 (0.4, 0.48)	NA (NA, NA)	0.32 (0.16, 0.48)	0.37 (0.18, 0.47)					0.46 (0.46, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.166 (0.111, 0.303)	0.147 (0.093, 0.267)	0.168 (0.065, 0.481)	0.142 (0.086, 0.227)					0.402 (0.08, 0.723)	0.163 (0.041, 0.47)	0 (0, 0)	0.149 (0, 0.609)					0.22 (0.065, 0.952)	0 (0, 0)	0.154 (0.083, 0.436)	0.14 (0.078, 0.347)					0.245 (0, 1.737)	0.28 (0.108, 0.451)	0 (0, 0.319)	0.614 (0.134, 3.205)
TEfus+	TC1	count			92	92			92	92			92	92			92	92			92	92			92	92			92	92			92	92
TEfus+	TC1	time			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)
TEfus+	TC1	n			2 (0, 4)	3 (1, 8)			3 (0, 5)	5 (2, 10)			3 (0, 7)	1 (0, 4)			0 (0, 0)	1 (0, 2)			2 (1, 5)	1 (0, 3)			5 (3, 10)	4 (2, 11)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.4 (0.23, 0.48)	0.37 (0.18, 0.48)			0.39 (0.25, 0.47)	0.31 (0.15, 0.46)			0.38 (0.24, 0.48)	0.41 (0.31, 0.47)			NA (NA, NA)	0.43 (0.37, 0.48)			0.38 (0.24, 0.48)	0.43 (0.32, 0.48)			0.31 (0.13, 0.44)	0.33 (0.15, 0.47)			0.45 (0.36, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.186 (0.075, 0.824)	0.14 (0.087, 0.474)			0.144 (0.088, 0.431)	0.144 (0.087, 0.334)			0.161 (0.096, 0.48)	0.168 (0.076, 0.496)			0.114 (0.086, 0.142)	0.188 (0.07, 0.591)			0.154 (0.077, 0.511)	0.195 (0.076, 0.589)			0.144 (0.092, 0.349)	0.136 (0.08, 0.46)			0.165 (0, 0.842)	0 (0, 0)			0 (0, 0)	0.063 (0.013, 0.37)
TEfus+	TC3	count			104	104			104	104			104	104			104	104			104	104			104	104			104	104			104	104
TEfus+	TC3	time			26 (17, 33)	26 (17, 33)			26 (17, 33)	26 (17, 33)			26 (17, 33)	26 (17, 33)			26 (17, 33)	26 (17, 33)			26 (17, 33)	26 (17, 33)			26 (17, 33)	26 (17, 33)			26 (17, 33)	26 (17, 33)			26 (17, 33)	26 (17, 33)
TEfus+	TC3	n			2 (0, 3)	3 (1, 7)			2 (0, 4)	4 (2, 10)			5 (2, 10)	2 (0, 4)			0 (0, 0)	1 (0, 3)			2 (1, 5)	1 (0, 3)			5 (2, 11)	4 (2, 9)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.41 (0.32, 0.49)	0.37 (0.21, 0.46)			0.38 (0.25, 0.47)	0.35 (0.16, 0.47)			0.35 (0.13, 0.48)	0.4 (0.28, 0.48)			NA (NA, NA)	0.42 (0.31, 0.48)			0.41 (0.27, 0.47)	0.42 (0.33, 0.48)			0.32 (0.13, 0.47)	0.33 (0.2, 0.45)			0.44 (0.4, 0.49)	0.45 (0.45, 0.45)			0.41 (0.41, 0.41)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.164 (0.065, 0.449)	0.158 (0.092, 0.529)			0.17 (0.09, 0.459)	0.15 (0.092, 0.353)			0.134 (0.088, 0.347)	0.16 (0.088, 0.576)			0.28 (0.056, 0.505)	0.171 (0.076, 0.795)			0.164 (0.075, 0.626)	0.135 (0.047, 0.889)			0.137 (0.085, 0.283)	0.15 (0.094, 0.344)			0.159 (0, 0.845)	0.228 (0.101, 0.567)			0.162 (0.022, 0.506)	0.124 (0.063, 0.185)
TEfus+	TC4	count			90	90			90	90			90	90			90	90			90	90			90	90			90	90			90	90
TEfus+	TC4	time			30 (20, 35)	30 (20, 35)			30 (20, 35)	30 (20, 35)			30 (20, 35)	30 (20, 35)			30 (20, 35)	30 (20, 35)			30 (20, 35)	30 (20, 35)			30 (20, 35)	30 (20, 35)			30 (20, 35)	30 (20, 35)			30 (20, 35)	30 (20, 35)
TEfus+	TC4	n			2 (0, 5)	4 (1, 9)			2 (0, 5)	5 (2, 11)			5 (2, 9)	3 (1, 5)			0 (0, 0)	2 (0, 4)			2 (1, 5)	1 (0, 4)			6 (2, 12)	4 (2, 10)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.41 (0.29, 0.49)	0.35 (0.18, 0.48)			0.41 (0.22, 0.48)	0.3 (0.15, 0.45)			0.3 (0.13, 0.45)	0.4 (0.25, 0.48)			NA (NA, NA)	0.41 (0.28, 0.49)			0.38 (0.21, 0.46)	0.38 (0.29, 0.49)			0.26 (0.13, 0.43)	0.31 (0.15, 0.45)			0.44 (0.37, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.173 (0.084, 1.058)	0.166 (0.085, 0.591)			0.146 (0.088, 0.423)	0.152 (0.09, 0.471)			0.148 (0.086, 0.35)	0.156 (0.08, 0.326)			0 (0, 0)	0.174 (0.073, 0.609)			0.161 (0.091, 0.687)	0.191 (0.075, 0.886)			0.138 (0.091, 0.268)	0.154 (0.09, 0.35)			0.179 (0.045, 0.64)	0 (0, 0)			0.169 (0.034, 0.648)	0 (0, 0)
TEfus+	TC5	count			92	92			92	92			92	92			92	92			92	92			92	92			92	92			92	92
TEfus+	TC5	time			27 (16, 35)	27 (16, 35)			27 (16, 35)	27 (16, 35)			27 (16, 35)	27 (16, 35)			27 (16, 35)	27 (16, 35)			27 (16, 35)	27 (16, 35)			27 (16, 35)	27 (16, 35)			27 (16, 35)	27 (16, 35)			27 (16, 35)	27 (16, 35)
TEfus+	TC5	n			2 (0, 4)	5 (2, 9)			2 (0, 5)	6 (3, 11)			4 (1, 8)	1 (0, 3)			0 (0, 0)	1 (0, 2)			2 (0, 5)	1 (0, 4)			4 (2, 9)	4 (2, 9)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.4 (0.23, 0.49)	0.35 (0.18, 0.48)			0.42 (0.29, 0.49)	0.29 (0.13, 0.45)			0.39 (0.18, 0.48)	0.42 (0.29, 0.47)			NA (NA, NA)	0.43 (0.32, 0.48)			0.4 (0.24, 0.48)	0.43 (0.3, 0.49)			0.34 (0.14, 0.46)	0.34 (0.17, 0.47)			0.46 (0.42, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.186 (0.068, 0.649)	0.148 (0.086, 0.29)			0.149 (0.068, 0.594)	0.13 (0.088, 0.27)			0.139 (0.087, 0.352)	0.181 (0.079, 0.579)			NA (NA, NA)	0.148 (0, 1.015)			0.18 (0.061, 0.691)	0.184 (0.058, 0.603)			0.138 (0.093, 0.287)	0.132 (0.079, 0.247)			0.087 (0, 0.268)	0.325 (0.325, 0.325)			0.073 (0.015, 0.131)	0.151 (0.129, 0.172)
PI3K+	TC1	count		58		58		58		58		58		58		58		58		58		58		58		58		58		58		58		58
PI3K+	TC1	time		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)		26 (17, 33)
PI3K+	TC1	n		7 (3, 13)		3 (0, 6)		6 (3, 12)		6 (2, 10)		0 (0, 0)		1 (0, 3)		1 (0, 3)		1 (0, 2)		1 (0, 2)		2 (0, 4)		0 (0, 0)		4 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.32 (0.18, 0.48)		0.36 (0.21, 0.48)		0.37 (0.18, 0.48)		0.34 (0.16, 0.48)		NA (NA, NA)		0.43 (0.32, 0.48)		0.44 (0.35, 0.49)		0.4 (0.3, 0.48)		0.45 (0.35, 0.49)		0.43 (0.36, 0.48)		NA (NA, NA)		0.31 (0.16, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.143 (0.109, 0.301)		0.133 (0.079, 0.387)		0.151 (0.111, 0.288)		0.139 (0.087, 0.544)		0.024 (0.005, 0.042)		0.206 (0.092, 0.603)		0.184 (0.085, 0.978)		0.192 (0.065, 0.65)		0.199 (0.008, 0.498)		0.139 (0.071, 0.483)		0.041 (0.008, 0.246)		0.165 (0.095, 0.322)		0.139 (0.057, 0.146)		NA (NA, NA)		0.063 (0.013, 0.113)		0.07 (0.07, 0.071)
PI3K+	TC2	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC2	time		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)		18 (16, 20)
PI3K+	TC2	n		6 (5, 6)		6 (4, 8)		5 (5, 5)		2 (1, 4)		0 (0, 0)		0 (0, 1)		1 (1, 1)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 1)		6 (6, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.18 (0.06, 0.3)		0.44 (0.41, 0.46)		0.34 (0.27, 0.42)		0.36 (0.33, 0.4)		NA (NA, NA)		0.31 (0.31, 0.31)		0.46 (0.46, 0.46)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.47 (0.45, 0.49)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.325 (0.18, 0.47)		0.095 (0.072, 0.118)		0.198 (0.163, 0.233)		2.172 (0.523, 3.822)		NA (NA, NA)		0.54 (0.54, 0.54)		0.347 (0.249, 0.445)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.353 (0.353, 0.353)		0.09 (0.073, 0.106)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	count		59		59		59		59		59		59		59		59		59		59		59		59		59		59		59		59
PI3K+	TC3	time		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)
PI3K+	TC3	n		6 (3, 17)		3 (1, 8)		6 (3, 11)		5 (3, 10)		0 (0, 0)		1 (0, 4)		1 (0, 3)		1 (0, 3)		0 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 1)
PI3K+	TC3	post_p		0.34 (0.17, 0.45)		0.36 (0.22, 0.46)		0.33 (0.17, 0.46)		0.35 (0.2, 0.48)		NA (NA, NA)		0.41 (0.28, 0.5)		0.41 (0.32, 0.46)		0.44 (0.32, 0.47)		0.42 (0.39, 0.49)		0.42 (0.32, 0.47)		NA (NA, NA)		0.31 (0.16, 0.45)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.152 (0.113, 0.261)		0.16 (0.086, 0.583)		0.163 (0.112, 0.351)		0.123 (0.095, 0.216)		0.122 (0.122, 0.122)		0.175 (0.07, 0.537)		0.155 (0.037, 0.909)		0.169 (0.044, 0.724)		0.245 (0.067, 1.215)		0.172 (0.07, 1.069)		0.114 (0.023, 0.206)		0.151 (0.09, 0.408)		0.117 (0.021, 0.217)		0.311 (0.141, 0.329)		0.068 (0.014, 0.085)		0.083 (0, 0.873)
PI3K+	TC4	count		63		63		63		63		63		63		63		63		63		63		63		63		63		63		63		63
PI3K+	TC4	time		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)		24 (18, 34)
PI3K+	TC4	n		6 (3, 14)		3 (1, 8)		5 (3, 10)		5 (2, 9)		0 (0, 0)		2 (0, 4)		1 (0, 2)		1 (0, 3)		0 (0, 2)		2 (0, 4)		0 (0, 0)		5 (2, 9)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.32 (0.18, 0.46)		0.41 (0.21, 0.49)		0.35 (0.19, 0.46)		0.3 (0.14, 0.45)		NA (NA, NA)		0.39 (0.25, 0.48)		0.44 (0.35, 0.48)		0.41 (0.35, 0.47)		0.44 (0.38, 0.5)		0.41 (0.27, 0.47)		NA (NA, NA)		0.38 (0.19, 0.46)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.15 (0.115, 0.232)		0.169 (0.082, 0.398)		0.148 (0.11, 0.326)		0.153 (0.093, 0.662)		0 (0, 0)		0.145 (0.077, 0.319)		0.157 (0.034, 1.667)		0.187 (0.063, 1.261)		0.176 (0.054, 1.072)		0.189 (0.049, 0.487)		NA (NA, NA)		0.125 (0.079, 0.263)		0.119 (0.119, 0.119)		NA (NA, NA)		0.501 (0.215, 0.787)		NA (NA, NA)
PI3K+	TC5	count		92		92		92		92		92		92		92		92		92		92		92		92		92		92		92		92
PI3K+	TC5	time		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)		17 (11, 31)
PI3K+	TC5	n		8 (4, 13)		4 (2, 8)		6 (3, 12)		5 (2, 9)		0 (0, 0)		1 (0, 3)		0 (0, 2)		1 (0, 2)		0 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 9)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.35 (0.17, 0.48)		0.38 (0.22, 0.47)		0.38 (0.16, 0.48)		0.34 (0.16, 0.47)		NA (NA, NA)		0.44 (0.29, 0.49)		0.43 (0.35, 0.49)		0.44 (0.35, 0.5)		0.44 (0.36, 0.48)		0.42 (0.27, 0.48)		NA (NA, NA)		0.36 (0.21, 0.47)		0.44 (0.44, 0.44)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.15 (0.109, 0.242)		0.142 (0.085, 0.492)		0.148 (0.093, 0.357)		0.137 (0.087, 0.286)		0.244 (0.244, 0.244)		0.161 (0, 0.4)		0.19 (0, 0.576)		0.148 (0, 1)		0.192 (0, 0.497)		0.168 (0, 0.693)		NA (NA, NA)		0.134 (0.086, 0.383)		4.63 (1.12, 8.14)		0.216 (0.128, 0.303)		0.065 (0.065, 0.065)		0.122 (0.029, 0.592)