Setting description

TC2 more effective in the TEfus+ biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.087, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 11.3, median = 8.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
all effect af = 1, hr = 1 af = 1, hr = 1 af = 1.28, hr = 0.77 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10, median = 7.2 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
AR- & TP53- effect af = 1, hr = 1 af = 1, hr = 1 af = 1.14, hr = 0.87 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.084, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 11.7, median = 8.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1.33, hr = 0.74 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.071, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.8, median = 9.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1.57, hr = 0.62 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.074, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.3, median = 9.6 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1.52, hr = 0.65 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 7 30 2 5 2
AR- & TP53- 27 59 8 7 5
HRD+ 1 36 7 5 6
TP53+ 0 60 2 0 2
TEfus+ 0 228 0 0 0
PI3K+ 0 63 1 0 4
TC1 TC2 TC3 TC4 TC5
all 0.014 0.060 0.004 0.010 0.004
AR- & TP53- 0.054 0.118 0.016 0.014 0.010
HRD+ 0.002 0.072 0.014 0.010 0.012
TP53+ 0.000 0.120 0.004 0.000 0.004
TEfus+ 0.000 0.456 0.000 0.000 0.000
PI3K+ 0.000 0.126 0.002 0.000 0.008
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 13 0 4 0 5
AR- & TP53- 125 8 121 124 100
HRD+ 23 0 41 52 28
TP53+ 100 0 87 77 109
TEfus+ 92 0 104 90 92
PI3K+ 58 2 59 63 92
TC1 TC2 TC3 TC4 TC5
all 0.026 0.000 0.008 0.000 0.010
AR- & TP53- 0.250 0.016 0.242 0.248 0.200
HRD+ 0.046 0.000 0.082 0.104 0.056
TP53+ 0.200 0.000 0.174 0.154 0.218
TEfus+ 0.184 0.000 0.208 0.180 0.184
PI3K+ 0.116 0.004 0.118 0.126 0.184
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 52 34 41 42 36
HRD+ 0 0 0 0 0
TP53+ 0 1 0 0 0
TEfus+ 0 1 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.000 0.000
AR- & TP53- 0.104 0.068 0.082 0.084 0.072
HRD+ 0.000 0.000 0.000 0.000 0.000
TP53+ 0.000 0.002 0.000 0.000 0.000
TEfus+ 0.000 0.002 0.000 0.000 0.000
PI3K+ 0.000 0.000 0.000 0.000 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.342 0.068 0.210 0.04 0.032 0.036
err_type 0.498 0.068 0.406 0.04 0.032 0.036
pow_sign 0.456 0.000 0.456 0.00 0.000 0.000
pow_type 0.666 0.000 0.666 0.00 0.000 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 7 30 2 5 2
all futility 0 13 0 4 0 5
all max_n 0 0 0 0 0 0
all n 375 (336, 417) 160 (93, 220) 169 (93, 235) 157 (99, 218) 158 (101, 220) 156 (98, 213)
all n_unique 346 (310, 384) 147 (85, 204) 154 (84, 218) 144 (91, 202) 144 (92, 203) 142 (90, 198)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 4 (3, 9) 7 (5, 17) 15 (8, 26) 8 (6, 9) 20 (6, 24)
all post_p NA (NA, NA) 0.12 (0.01, 0.51) 1 (0.96, 1) 0.1 (0.01, 0.48) 0.1 (0.01, 0.51) 0.1 (0.01, 0.48)
all rate 0.098 (0.091, 0.106) 0.113 (0.101, 0.128) 0.069 (0.059, 0.081) 0.114 (0.101, 0.13) 0.113 (0.101, 0.128) 0.113 (0.102, 0.129)
AR- & TP53- graduation 0 27 59 8 7 5
AR- & TP53- futility 0 125 8 121 124 100
AR- & TP53- max_n 0 52 34 41 42 36
AR- & TP53- n 219 (188, 251) 90 (28, 150) 82 (29, 139) 87 (36, 147) 85 (36, 145) 88 (38, 139)
AR- & TP53- n_unique 203 (174, 235) 84 (26, 139) 75 (27, 129) 80 (32, 137) 78 (33, 136) 80 (35, 130)
AR- & TP53- time_trial 36 (36, 36) 36 (8, 36) 36 (15, 36) 36 (19, 36) 36 (18, 36) 36 (21, 36)
AR- & TP53- time_stop NA (NA, NA) 11 (6, 28) 11 (9, 19) 21 (12, 33) 21 (12, 31) 21 (12, 33)
AR- & TP53- post_p NA (NA, NA) 0.33 (0.04, 0.75) 0.9 (0.48, 0.99) 0.26 (0.03, 0.78) 0.3 (0.04, 0.71) 0.29 (0.04, 0.73)
AR- & TP53- rate 0.105 (0.096, 0.115) 0.114 (0.098, 0.138) 0.087 (0.072, 0.104) 0.116 (0.098, 0.141) 0.114 (0.099, 0.14) 0.115 (0.099, 0.138)
HRD+ graduation 0 1 36 7 5 6
HRD+ futility 0 23 0 41 52 28
HRD+ max_n 0 0 0 0 0 0
HRD+ n 59 (49, 71) 24 (9, 38) 26 (11, 40) 31 (19, 48) 29 (19, 45) 27 (15, 43)
HRD+ n_unique 54 (44, 66) 21 (8, 35) 24 (9, 37) 28 (17, 44) 27 (18, 41) 24 (13, 38)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
HRD+ time_stop NA (NA, NA) 31 (23, 35) 29 (23, 34) 29 (21, 35) 28 (21, 36) 30 (24, 35)
HRD+ post_p NA (NA, NA) 0.33 (0.07, 0.73) 0.87 (0.41, 0.99) 0.28 (0.04, 0.71) 0.28 (0.05, 0.69) 0.29 (0.06, 0.7)
HRD+ rate 0.096 (0.079, 0.119) 0.116 (0.085, 0.161) 0.071 (0.05, 0.105) 0.114 (0.092, 0.156) 0.115 (0.091, 0.153) 0.115 (0.088, 0.158)
TP53+ graduation 0 0 60 2 0 2
TP53+ futility 0 100 0 87 77 109
TP53+ max_n 0 0 1 0 0 0
TP53+ n 129 (113, 149) 54 (28, 79) 66 (28, 99) 54 (28, 79) 55 (30, 83) 53 (29, 78)
TP53+ n_unique 118 (102, 137) 49 (26, 71) 60 (25, 92) 48 (26, 72) 50 (28, 76) 48 (26, 71)
TP53+ time_trial 36 (36, 36) 36 (23, 36) 36 (25, 36) 36 (26, 36) 36 (29, 36) 36 (21, 36)
TP53+ time_stop NA (NA, NA) 23 (15, 34) 15 (11, 28) 25 (16, 34) 27 (17, 34) 22 (14, 32)
TP53+ post_p NA (NA, NA) 0.12 (0.01, 0.52) 1 (0.93, 1) 0.12 (0.01, 0.49) 0.12 (0.01, 0.48) 0.1 (0.01, 0.46)
TP53+ rate 0.089 (0.078, 0.102) 0.114 (0.094, 0.15) 0.053 (0.042, 0.068) 0.115 (0.094, 0.145) 0.113 (0.095, 0.143) 0.116 (0.095, 0.146)
TEfus+ graduation 0 0 228 0 0 0
TEfus+ futility 0 92 0 104 90 92
TEfus+ max_n 0 0 1 0 0 0
TEfus+ n 123 (108, 142) 47 (27, 73) 69 (26, 107) 49 (30, 75) 50 (32, 78) 51 (30, 74)
TEfus+ n_unique 113 (98, 130) 42 (25, 66) 63 (23, 99) 44 (28, 68) 46 (29, 70) 46 (27, 65)
TEfus+ time_trial 36 (36, 36) 36 (28, 36) 36 (14, 36) 36 (26, 36) 36 (31, 36) 36 (28, 36)
TEfus+ time_stop NA (NA, NA) 26 (17, 34) 19 (12, 31) 26 (17, 33) 30 (20, 35) 27 (16, 35)
TEfus+ post_p NA (NA, NA) 0.04 (0, 0.28) 1 (1, 1) 0.03 (0, 0.19) 0.03 (0, 0.23) 0.03 (0, 0.23)
TEfus+ rate 0.075 (0.065, 0.089) 0.114 (0.093, 0.147) 0.036 (0.028, 0.044) 0.116 (0.095, 0.142) 0.114 (0.093, 0.143) 0.115 (0.095, 0.141)
PI3K+ graduation 0 0 63 1 0 4
PI3K+ futility 0 58 2 59 63 92
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 126 (110, 146) 51 (26, 75) 56 (25, 87) 53 (30, 79) 55 (30, 81) 58 (30, 85)
PI3K+ n_unique 116 (100, 134) 46 (25, 69) 51 (23, 80) 48 (27, 72) 49 (27, 74) 53 (28, 79)
PI3K+ time_trial 36 (36, 36) 36 (33, 36) 36 (25, 36) 36 (32, 36) 36 (31, 36) 36 (17, 36)
PI3K+ time_stop NA (NA, NA) 26 (17, 33) 20 (13, 28) 24 (17, 34) 24 (18, 34) 16 (11, 30)
PI3K+ post_p NA (NA, NA) 0.16 (0.02, 0.55) 0.99 (0.86, 1) 0.13 (0.02, 0.54) 0.14 (0.02, 0.55) 0.11 (0.01, 0.46)
PI3K+ rate 0.092 (0.081, 0.105) 0.114 (0.093, 0.143) 0.057 (0.044, 0.073) 0.115 (0.094, 0.142) 0.114 (0.093, 0.142) 0.116 (0.096, 0.142)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 33 86 10 12 7
—– futility 0 133 8 122 124 101
—– max_n 0 52 34 41 42 36
—– n 124 (100, 151) 44 (18, 99) 38 (13, 94) 38 (10, 93) 42 (11, 92) 38 (10, 87)
—– n_unique 117 (92, 141) 41 (17, 95) 36 (12, 89) 36 (9, 88) 39 (10, 88) 36 (9, 84)
—– post_p NA (NA, NA) 0.49 (0.13, 0.88) 0.48 (0.12, 0.89) 0.44 (0.1, 0.88) 0.46 (0.1, 0.87) 0.42 (0.09, 0.87)
—– rate 0.114 (0.1, 0.128) 0.116 (0.096, 0.153) 0.115 (0.094, 0.166) 0.117 (0.095, 0.179) 0.118 (0.095, 0.175) 0.119 (0.094, 0.194)
—-+ graduation 0 31 128 11 12 11
—-+ futility 0 167 10 151 157 161
—-+ max_n 0 52 34 40 42 36
—-+ n 31 (23, 40) 9 (3, 25) 8 (2, 21) 11 (4, 27) 10 (3, 24) 13 (5, 28)
—-+ n_unique 28 (21, 38) 8 (3, 24) 7 (2, 19) 10 (3, 24) 9 (3, 22) 13 (4, 26)
—-+ post_p NA (NA, NA) 0.44 (0.17, 0.87) 0.45 (0.16, 0.83) 0.46 (0.16, 0.85) 0.44 (0.16, 0.84) 0.46 (0.16, 0.84)
—-+ rate 0.113 (0.087, 0.146) 0.122 (0.077, 0.261) 0.123 (0.074, 0.278) 0.123 (0.081, 0.246) 0.123 (0.082, 0.255) 0.12 (0.087, 0.208)
—+- graduation 0 30 266 8 11 7
—+- futility 0 189 7 185 174 156
—+- max_n 0 50 33 38 39 34
—+- n 5 (2, 9) 2 (0, 5) 2 (0, 6) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- n_unique 5 (2, 8) 2 (0, 5) 2 (0, 6) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- post_p NA (NA, NA) 0.42 (0.24, 0.59) 0.7 (0.45, 0.9) 0.41 (0.26, 0.62) 0.42 (0.25, 0.62) 0.41 (0.23, 0.64)
—+- rate 0.078 (0.03, 0.187) 0.131 (0.059, 0.495) 0.032 (0, 0.131) 0.137 (0.046, 0.397) 0.135 (0.047, 0.537) 0.132 (0.049, 0.499)
—++ graduation 0 28 286 9 11 11
—++ futility 0 209 9 203 197 198
—++ max_n 0 50 33 38 39 34
—++ n 14 (10, 19) 4 (1, 11) 5 (1, 13) 4 (1, 11) 5 (1, 12) 6 (3, 12)
—++ n_unique 13 (8, 18) 4 (1, 10) 4 (0, 12) 4 (1, 10) 4 (1, 11) 5 (2, 11)
—++ post_p NA (NA, NA) 0.36 (0.16, 0.64) 0.83 (0.47, 0.98) 0.34 (0.16, 0.61) 0.35 (0.17, 0.62) 0.32 (0.16, 0.61)
—++ rate 0.077 (0.049, 0.123) 0.123 (0.07, 0.296) 0.036 (0.01, 0.108) 0.133 (0.069, 0.45) 0.131 (0.07, 0.36) 0.129 (0.076, 0.259)
–+– graduation 0 7 86 4 5 4
–+– futility 0 112 0 89 77 110
–+– max_n 0 0 1 0 0 0
–+– n 26 (18, 35) 11 (4, 25) 9 (3, 22) 10 (3, 22) 10 (3, 24) 10 (4, 22)
–+– n_unique 24 (17, 32) 11 (4, 22) 8 (3, 20) 9 (3, 21) 9 (3, 22) 9 (3, 21)
–+– post_p NA (NA, NA) 0.45 (0.16, 0.85) 0.47 (0.16, 0.81) 0.43 (0.17, 0.84) 0.46 (0.16, 0.83) 0.43 (0.18, 0.87)
–+– rate 0.113 (0.084, 0.147) 0.12 (0.085, 0.233) 0.123 (0.079, 0.264) 0.129 (0.081, 0.271) 0.119 (0.082, 0.288) 0.124 (0.077, 0.249)
–+-+ graduation 0 7 135 5 5 7
–+-+ futility 0 142 2 122 115 163
–+-+ max_n 0 0 1 0 0 0
–+-+ n 26 (19, 33) 10 (3, 22) 7 (3, 20) 10 (3, 22) 10 (3, 23) 10 (4, 24)
–+-+ n_unique 23 (17, 32) 9 (3, 20) 6 (2, 18) 9 (3, 20) 9 (3, 21) 9 (4, 22)
–+-+ post_p NA (NA, NA) 0.46 (0.17, 0.86) 0.47 (0.17, 0.85) 0.45 (0.18, 0.83) 0.47 (0.19, 0.84) 0.42 (0.13, 0.83)
–+-+ rate 0.113 (0.083, 0.151) 0.119 (0.078, 0.266) 0.12 (0.078, 0.282) 0.123 (0.079, 0.261) 0.125 (0.08, 0.264) 0.127 (0.083, 0.254)
–++- graduation 0 7 277 4 5 4
–++- futility 0 171 0 158 141 167
–++- max_n 0 0 2 0 0 0
–++- n 7 (4, 11) 3 (1, 6) 4 (1, 10) 3 (1, 7) 3 (1, 6) 3 (1, 6)
–++- n_unique 7 (3, 11) 3 (1, 6) 4 (1, 9) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.38 (0.22, 0.65) 0.75 (0.46, 0.95) 0.38 (0.2, 0.65) 0.39 (0.22, 0.62) 0.4 (0.22, 0.63)
–++- rate 0.076 (0.042, 0.154) 0.133 (0.057, 0.42) 0.039 (0.008, 0.103) 0.138 (0.055, 0.455) 0.126 (0.057, 0.355) 0.137 (0.057, 0.411)
–+++ graduation 0 7 300 5 5 7
–+++ futility 0 193 2 181 167 208
–+++ max_n 0 0 2 0 0 0
–+++ n 21 (15, 29) 6 (2, 15) 10 (2, 22) 6 (2, 15) 6 (3, 17) 7 (3, 15)
–+++ n_unique 20 (13, 27) 6 (2, 13) 9 (2, 20) 5 (2, 14) 6 (2, 15) 6 (3, 14)
–+++ post_p NA (NA, NA) 0.29 (0.11, 0.62) 0.93 (0.62, 1) 0.3 (0.13, 0.62) 0.3 (0.12, 0.61) 0.28 (0.1, 0.59)
–+++ rate 0.079 (0.053, 0.115) 0.132 (0.073, 0.309) 0.037 (0.019, 0.07) 0.125 (0.072, 0.318) 0.132 (0.074, 0.308) 0.125 (0.079, 0.247)
-+— graduation 0 34 121 17 16 12
-+— futility 0 150 8 149 160 125
-+— max_n 0 52 34 39 39 35
-+— n 26 (19, 33) 7 (1, 19) 9 (2, 19) 11 (4, 26) 10 (4, 22) 10 (3, 22)
-+— n_unique 23 (17, 31) 6 (1, 18) 8 (2, 18) 10 (4, 24) 9 (4, 21) 9 (3, 20)
-+— post_p NA (NA, NA) 0.44 (0.18, 0.83) 0.48 (0.17, 0.84) 0.48 (0.17, 0.85) 0.45 (0.15, 0.82) 0.43 (0.18, 0.82)
-+— rate 0.113 (0.087, 0.154) 0.125 (0.078, 0.356) 0.12 (0.08, 0.268) 0.122 (0.083, 0.222) 0.124 (0.085, 0.236) 0.125 (0.084, 0.273)
-+–+ graduation 0 32 156 18 16 16
-+–+ futility 0 183 10 174 191 179
-+–+ max_n 0 52 34 38 39 35
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.51 (0.46, 0.55) NA (NA, NA) 0.58 (0.58, 0.58) 0.51 (0.48, 0.53) 0.5 (0.45, 0.54)
-+–+ rate 0.089 (0, 0.501) 0.118 (0.009, 0.467) 0.077 (0, 0.458) 0.144 (0.013, 2.434) 0.134 (0, 0.578) 0.12 (0, 6.39)
-+-+- graduation 0 31 280 14 15 11
-+-+- futility 0 203 7 202 203 178
-+-+- max_n 0 50 33 36 36 33
-+-+- n 13 (8, 19) 4 (0, 10) 4 (1, 13) 5 (2, 11) 5 (2, 11) 5 (2, 11)
-+-+- n_unique 12 (7, 17) 3 (0, 9) 4 (0, 12) 5 (2, 10) 5 (2, 11) 4 (1, 10)
-+-+- post_p NA (NA, NA) 0.38 (0.21, 0.66) 0.84 (0.48, 0.98) 0.32 (0.14, 0.58) 0.33 (0.15, 0.63) 0.34 (0.17, 0.63)
-+-+- rate 0.077 (0.046, 0.133) 0.119 (0.061, 0.346) 0.034 (0.01, 0.103) 0.129 (0.076, 0.305) 0.128 (0.071, 0.327) 0.125 (0.066, 0.335)
-+-++ graduation 0 29 300 15 15 15
-+-++ futility 0 222 9 216 225 215
-+-++ max_n 0 50 33 36 36 33
-+-++ n 5 (2, 9) 2 (0, 5) 2 (0, 5) 3 (1, 6) 3 (1, 6) 2 (0, 5)
-+-++ n_unique 5 (2, 8) 1 (0, 4) 2 (0, 5) 2 (0, 5) 2 (1, 5) 2 (0, 5)
-+-++ post_p NA (NA, NA) 0.42 (0.25, 0.66) 0.68 (0.43, 0.88) 0.4 (0.23, 0.63) 0.41 (0.23, 0.64) 0.41 (0.26, 0.63)
-+-++ rate 0.077 (0.03, 0.188) 0.144 (0.049, 0.575) 0.041 (0, 0.146) 0.135 (0.059, 0.394) 0.13 (0.057, 0.383) 0.139 (0.056, 0.462)
-++– graduation 0 7 118 11 9 10
-++– futility 0 133 0 122 117 130
-++– max_n 0 0 1 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.51 (0.48, 0.53) 0.47 (0.43, 0.5) 0.49 (0.49, 0.49) 0.47 (0.4, 0.55) NA (NA, NA)
-++– rate 0.108 (0, 0.535) 0.107 (0, 1.295) 0.099 (0, 0.391) 0.122 (0, 0.732) 0.121 (0, 0.371) 0.091 (0, 0.806)
-++-+ graduation 0 7 163 12 9 13
-++-+ futility 0 160 2 150 150 180
-++-+ max_n 0 0 1 0 0 0
-++-+ n 3 (1, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++-+ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 3) 1 (0, 4) 1 (0, 4) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.47 (0.31, 0.68) 0.47 (0.33, 0.73) 0.49 (0.33, 0.71) 0.46 (0.32, 0.68) 0.47 (0.34, 0.71)
-++-+ rate 0.12 (0.035, 0.43) 0.158 (0.04, 0.779) 0.135 (0.024, 0.591) 0.127 (0.034, 0.467) 0.137 (0.043, 0.465) 0.139 (0, 0.576)
-+++- graduation 0 7 292 10 8 9
-+++- futility 0 189 0 182 173 184
-+++- max_n 0 0 2 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.43 (0.4, 0.44) 0.54 (0.53, 0.55) 0.54 (0.54, 0.54) 0.48 (0.46, 0.58) NA (NA, NA)
-+++- rate 0.159 (0, 0.616) 0.114 (0, 1.49) 0.051 (0, 0.404) 0.185 (0, 1.235) 0.18 (0, 0.456) 0.205 (0.006, 9.89)
-++++ graduation 0 7 315 11 8 12
-++++ futility 0 209 2 200 195 222
-++++ max_n 0 0 2 0 0 0
-++++ n 3 (1, 6) 1 (0, 3) 1 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ n_unique 3 (1, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.44 (0.3, 0.64) 0.63 (0.44, 0.82) 0.44 (0.29, 0.62) 0.43 (0.28, 0.62) 0.44 (0.31, 0.63)
-++++ rate 0.077 (0, 0.261) 0.136 (0.033, 0.572) 0.037 (0, 0.198) 0.134 (0.036, 0.472) 0.135 (0.045, 0.523) 0.14 (0.036, 0.607)
+—- graduation 0 7 30 2 5 2
+—- futility 0 13 0 4 0 5
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 8) 3 (1, 6) 3 (1, 6) 2 (1, 5) 2 (0, 5) 2 (1, 5)
+—- n_unique 4 (1, 7) 2 (1, 5) 2 (1, 5) 2 (0, 4) 2 (0, 5) 2 (0, 5)
+—- post_p NA (NA, NA) 0.49 (0.3, 0.76) 0.47 (0.25, 0.74) 0.47 (0.29, 0.75) 0.48 (0.27, 0.73) 0.49 (0.28, 0.74)
+—- rate 0.115 (0.059, 0.271) 0.131 (0.049, 0.44) 0.134 (0.054, 0.474) 0.137 (0.046, 0.562) 0.135 (0.039, 0.475) 0.131 (0.044, 0.476)
+—+ graduation 0 7 90 3 5 6
+—+ futility 0 71 2 60 63 93
+—+ max_n 0 0 0 0 0 0
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 1 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ post_p NA (NA, NA) 0.48 (0.33, 0.65) 0.48 (0.36, 0.69) 0.48 (0.35, 0.65) 0.48 (0.35, 0.68) 0.49 (0.33, 0.67)
+—+ rate 0.128 (0, 0.543) 0.135 (0, 0.49) 0.132 (0.044, 0.639) 0.141 (0, 0.77) 0.133 (0, 0.73) 0.124 (0, 0.524)
+–+- graduation 0 7 254 2 5 2
+–+- futility 0 104 0 106 90 94
+–+- max_n 0 0 1 0 0 0
+–+- n 7 (4, 12) 3 (1, 7) 4 (1, 10) 3 (1, 7) 3 (1, 6) 3 (1, 7)
+–+- n_unique 7 (3, 11) 3 (1, 6) 4 (1, 9) 3 (1, 6) 3 (1, 6) 3 (1, 6)
+–+- post_p NA (NA, NA) 0.37 (0.21, 0.62) 0.78 (0.5, 0.95) 0.4 (0.21, 0.67) 0.39 (0.21, 0.64) 0.39 (0.21, 0.65)
+–+- rate 0.081 (0.041, 0.145) 0.138 (0.058, 0.328) 0.037 (0.013, 0.089) 0.124 (0.05, 0.382) 0.128 (0.049, 0.408) 0.128 (0.052, 0.383)
+–++ graduation 0 7 282 3 5 6
+–++ futility 0 139 2 140 129 152
+–++ max_n 0 0 1 0 0 0
+–++ n 4 (1, 7) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 5)
+–++ n_unique 3 (1, 6) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4)
+–++ post_p NA (NA, NA) 0.43 (0.29, 0.63) 0.64 (0.44, 0.84) 0.43 (0.28, 0.62) 0.44 (0.29, 0.64) 0.44 (0.28, 0.64)
+–++ rate 0.072 (0, 0.195) 0.135 (0.045, 0.496) 0.041 (0, 0.162) 0.132 (0.048, 0.563) 0.128 (0.038, 0.474) 0.132 (0.052, 0.42)
+-+– graduation 0 7 86 4 5 4
+-+– futility 0 112 0 89 77 110
+-+– max_n 0 0 1 0 0 0
+-+– n 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.49 (0.38, 0.65) 0.48 (0.35, 0.66) 0.48 (0.36, 0.63) 0.49 (0.37, 0.63) 0.49 (0.39, 0.65)
+-+– rate 0.129 (0, 0.461) 0.124 (0, 0.522) 0.128 (0, 0.793) 0.154 (0.03, 0.65) 0.138 (0, 0.69) 0.135 (0, 0.557)
+-+-+ graduation 0 7 135 5 5 7
+-+-+ futility 0 142 2 122 115 163
+-+-+ max_n 0 0 1 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) 0.48 (0.48, 0.48) 0.5 (0.5, 0.5) 0.63 (0.63, 0.63)
+-+-+ rate 0.321 (0.043, 3.94) 0.182 (0, 0.504) 0.147 (0, 0.811) 0.146 (0, 0.923) 0.081 (0, 0.929) 0.069 (0, 0.78)
+-++- graduation 0 7 277 4 5 4
+-++- futility 0 171 0 158 141 167
+-++- max_n 0 0 2 0 0 0
+-++- n 23 (16, 31) 6 (3, 15) 13 (5, 26) 7 (3, 15) 7 (3, 16) 6 (3, 15)
+-++- n_unique 21 (15, 29) 6 (2, 14) 12 (4, 24) 6 (2, 13) 6 (3, 14) 6 (2, 13)
+-++- post_p NA (NA, NA) 0.28 (0.11, 0.58) 0.95 (0.71, 1) 0.26 (0.11, 0.56) 0.26 (0.12, 0.55) 0.28 (0.12, 0.58)
+-++- rate 0.074 (0.051, 0.112) 0.126 (0.075, 0.284) 0.036 (0.02, 0.061) 0.129 (0.079, 0.276) 0.129 (0.078, 0.275) 0.123 (0.075, 0.291)
+-+++ graduation 0 7 300 5 5 7
+-+++ futility 0 193 2 181 167 208
+-+++ max_n 0 0 2 0 0 0
+-+++ n 17 (11, 24) 5 (2, 13) 8 (2, 20) 6 (2, 14) 6 (2, 15) 6 (3, 12)
+-+++ n_unique 16 (10, 22) 4 (1, 12) 8 (2, 18) 5 (2, 13) 5 (2, 13) 5 (2, 11)
+-+++ post_p NA (NA, NA) 0.32 (0.15, 0.58) 0.9 (0.59, 0.99) 0.3 (0.14, 0.6) 0.32 (0.13, 0.63) 0.3 (0.13, 0.56)
+-+++ rate 0.076 (0.048, 0.113) 0.128 (0.075, 0.315) 0.037 (0.017, 0.069) 0.128 (0.075, 0.297) 0.125 (0.073, 0.289) 0.129 (0.079, 0.293)
++— graduation 0 8 66 9 10 8
++— futility 0 36 0 44 52 33
++— max_n 0 0 0 0 0 0
++— n 8 (4, 12) 3 (1, 8) 4 (1, 7) 4 (2, 8) 4 (2, 9) 4 (1, 8)
++— n_unique 7 (3, 11) 3 (1, 7) 3 (1, 7) 4 (1, 8) 4 (2, 8) 3 (1, 7)
++— post_p NA (NA, NA) 0.47 (0.24, 0.78) 0.47 (0.24, 0.79) 0.48 (0.25, 0.81) 0.5 (0.24, 0.8) 0.47 (0.27, 0.79)
++— rate 0.117 (0.065, 0.208) 0.13 (0.054, 0.402) 0.125 (0.053, 0.382) 0.121 (0.065, 0.302) 0.121 (0.061, 0.313) 0.126 (0.057, 0.366)
++–+ graduation 0 8 119 10 10 12
++–+ futility 0 91 2 94 105 114
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.53 (0.53, 0.53) 0.49 (0.49, 0.49) 0.5 (0.48, 0.53) 0.51 (0.49, 0.53) 0.47 (0.42, 0.55)
++–+ rate 0.1 (0, 0.964) 0.141 (0, 0.905) 0.09 (0, 0.389) 0.163 (0.018, 0.506) 0.169 (0, 3.103) 0.107 (0, 0.412)
++-+- graduation 0 8 269 8 9 7
++-+- futility 0 123 0 135 127 118
++-+- max_n 0 0 1 0 0 0
++-+- n 1 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.47 (0.39, 0.61) 0.55 (0.44, 0.65) 0.46 (0.39, 0.58) 0.46 (0.39, 0.59) 0.47 (0.39, 0.57)
++-+- rate 0.074 (0, 0.594) 0.138 (0, 0.639) 0.03 (0, 0.257) 0.15 (0, 0.638) 0.147 (0, 0.716) 0.14 (0, 0.849)
++-++ graduation 0 8 297 9 9 11
++-++ futility 0 156 2 163 162 170
++-++ max_n 0 0 1 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.47, 0.54) 0.45 (0.44, 0.46) NA (NA, NA)
++-++ rate 0.059 (0, 0.214) 0.213 (0, 0.428) 0 (0, 4.894) 0.179 (0, 1.008) 0.099 (0, 0.445) 0.139 (0, 0.711)
+++– graduation 0 7 118 11 9 10
+++– futility 0 133 0 122 117 130
+++– max_n 0 0 1 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.51 (0.46, 0.61) 0.5 (0.43, 0.55) 0.48 (0.42, 0.58) 0.49 (0.44, 0.56) 0.47 (0.38, 0.53)
+++– rate 0.137 (0, 0.573) 0.114 (0, 0.932) 0.147 (0, 0.684) 0.154 (0, 1.146) 0.132 (0, 0.795) 0.134 (0, 0.712)
+++-+ graduation 0 7 163 12 9 13
+++-+ futility 0 160 2 150 150 180
+++-+ max_n 0 0 1 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.48 (0.44, 0.52) NA (NA, NA) 0.56 (0.52, 0.6) 0.52 (0.44, 0.55) 0.46 (0.45, 0.53)
+++-+ rate 0.177 (0, 3.068) 0.156 (0.012, 0.831) 0.09 (0, 0.679) 0.101 (0, 0.677) 0.16 (0.028, 0.674) 0.171 (0, 1.359)
++++- graduation 0 7 292 10 8 9
++++- futility 0 189 0 182 173 184
++++- max_n 0 0 2 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) 0.55 (0.44, 0.65) 0.48 (0.47, 0.48) 0.46 (0.38, 0.46) 0.47 (0.45, 0.47) 0.55 (0.53, 0.58)
++++- rate 0.104 (0, 0.457) 0.129 (0, 0.691) 0.062 (0, 0.951) 0.178 (0.032, 1.048) 0.155 (0, 0.393) 0.146 (0, 0.996)
+++++ graduation 0 7 315 11 8 12
+++++ futility 0 209 2 200 195 222
+++++ max_n 0 0 2 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) 0.51 (0.48, 0.54) NA (NA, NA) 0.46 (0.46, 0.46)
+++++ rate 0.051 (0, 0.479) 0.149 (0.046, 1.098) 0 (0, 0.103) 0.182 (0, 1.453) 0.141 (0, 0.51) 0.178 (0.046, 1.036)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 7 30 2 5 2
all time_stop 4 (3, 6) 7 (5, 17) 8 (7, 8) 8 (6, 9) 6 (6, 7)
all n_trt 27 (25, 35) 33 (27, 73) 29 (26, 32) 29 (28, 44) 25 (25, 25)
all n_control 49 (32, 65) 63 (42, 148) 76 (74, 78) 67 (51, 71) 70 (63, 77)
all post_p 0.92 (0.88, 0.93) 0.97 (0.88, 1) 0.94 (0.92, 0.97) 0.94 (0.88, 0.95) 0.96 (0.94, 0.98)
all order 1 (1, 1.4) 1 (1, 2.1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
AR- & TP53- count 27 59 8 7 5
AR- & TP53- time_stop 7 (6, 9) 10 (8, 19) 10 (8, 12) 11 (9, 16) 13 (10, 17)
AR- & TP53- n_trt 31 (26, 43) 33 (26, 58) 28 (25, 36) 27 (26, 54) 43 (32, 47)
AR- & TP53- n_control 39 (33, 53) 57 (42, 91) 48 (42, 68) 61 (54, 90) 70 (51, 95)
AR- & TP53- post_p 0.9 (0.86, 0.95) 0.93 (0.86, 0.98) 0.93 (0.87, 0.96) 0.96 (0.88, 0.98) 0.95 (0.92, 0.95)
AR- & TP53- order 1 (1, 1) 1 (1, 2) 1 (1, 2) 1 (1, 1.4) 1 (1, 2)
HRD+ count 1 36 7 5 6
HRD+ time_stop 23 (23, 23) 29 (23, 34) 21 (19, 30) 20 (19, 25) 26 (20, 32)
HRD+ n_trt 25 (25, 25) 27 (25, 38) 27 (25, 35) 28 (25, 43) 26 (26, 31)
HRD+ n_control 40 (40, 40) 42 (28, 56) 34 (26, 53) 34 (27, 46) 35 (31, 42)
HRD+ post_p 0.92 (0.92, 0.92) 0.97 (0.89, 1) 0.93 (0.87, 0.95) 0.94 (0.88, 0.98) 0.9 (0.87, 0.92)
HRD+ order 2 (2, 2) 2 (1, 3) 1 (1, 2) 2 (2, 3) 2.5 (1, 3)
TP53+ count 60 2 2
TP53+ time_stop 15 (11, 28) 16 (16, 16) 11 (10, 12)
TP53+ n_trt 30 (25, 52) 28 (27, 28) 26 (25, 27)
TP53+ n_control 49 (31, 91) 46 (44, 48) 34 (34, 34)
TP53+ post_p 0.99 (0.93, 1) 0.95 (0.95, 0.95) 0.96 (0.95, 0.96)
TP53+ order 1 (1, 2) 2.5 (2.1, 2.9) 1.5 (1.1, 1.9)
TEfus+ count 228
TEfus+ time_stop 19 (12, 31)
TEfus+ n_trt 40 (25, 80)
TEfus+ n_control 56 (31, 99)
TEfus+ post_p 1 (0.98, 1)
TEfus+ order 1 (1, 2)
PI3K+ count 63 1 4
PI3K+ time_stop 20 (13, 28) 15 (15, 15) 14 (10, 14)
PI3K+ n_trt 32 (25, 57) 28 (28, 28) 26 (26, 35)
PI3K+ n_control 57 (32, 95) 49 (49, 49) 44 (29, 47)
PI3K+ post_p 0.98 (0.93, 1) 0.97 (0.97, 0.97) 0.9 (0.9, 0.94)
PI3K+ order 2 (1, 3) 1 (1, 1) 1.5 (1, 2)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 13 4 5
all time_stop 4 (3, 11) 22 (13, 28) 22 (12, 25)
all n_trt 28 (25, 55) 64 (40, 82) 74 (40, 107)
all n_control 42 (30, 88) 199 (118, 299) 212 (106, 260)
all post_p 0.08 (0, 0.22) 0 (0, 0.01) 0.01 (0, 0.02)
all order 1 (1, 1.8) 1.5 (1, 6.2) 4 (2.2, 7.2)
AR- & TP53- count 125 8 121 124 100
AR- & TP53- time_stop 13 (6, 30) 12 (9, 18) 21 (13, 33) 22 (13, 31) 21 (12, 33)
AR- & TP53- n_trt 36 (26, 78) 27 (26, 40) 45 (26, 90) 46 (26, 85) 42 (26, 80)
AR- & TP53- n_control 66 (32, 173) 70 (43, 81) 122 (66, 206) 118 (72, 181) 119 (61, 194)
AR- & TP53- post_p 0.12 (0.02, 0.25) 0.14 (0.03, 0.25) 0.07 (0.01, 0.2) 0.1 (0.02, 0.2) 0.09 (0.02, 0.21)
AR- & TP53- order 1 (1, 3) 1 (1, 2.3) 2 (1, 5) 2 (1, 4) 2 (1, 4.1)
HRD+ count 23 41 52 28
HRD+ time_stop 32 (24, 35) 29 (24, 35) 29 (21, 36) 30 (26, 35)
HRD+ n_trt 27 (25, 38) 29 (25, 41) 27 (25, 33) 27 (25, 33)
HRD+ n_control 49 (32, 60) 45 (30, 60) 43 (28, 60) 49 (34, 63)
HRD+ post_p 0.09 (0.04, 0.19) 0.14 (0.04, 0.29) 0.09 (0.03, 0.22) 0.08 (0.02, 0.22)
HRD+ order 3 (1, 4.8) 4 (2, 7) 3 (1, 5) 3 (2, 5)
TP53+ count 100 87 77 109
TP53+ time_stop 23 (15, 34) 25 (17, 34) 27 (17, 34) 22 (14, 32)
TP53+ n_trt 35 (25, 53) 29 (25, 50) 32 (25, 54) 33 (26, 49)
TP53+ n_control 72 (40, 115) 80 (49, 115) 89 (47, 121) 65 (36, 116)
TP53+ post_p 0.04 (0, 0.13) 0.03 (0, 0.14) 0.04 (0, 0.18) 0.05 (0.01, 0.18)
TP53+ order 2 (1, 5) 2 (1, 4.4) 2 (1, 5) 2 (1, 4)
TEfus+ count 92 104 90 92
TEfus+ time_stop 26 (17, 34) 26 (17, 33) 30 (20, 35) 27 (16, 35)
TEfus+ n_trt 33 (25, 57) 34 (25, 52) 37 (27, 63) 37 (25, 53)
TEfus+ n_control 80 (45, 121) 82 (47, 119) 98 (57, 125) 82 (42, 122)
TEfus+ post_p 0.01 (0, 0.08) 0.01 (0, 0.06) 0.01 (0, 0.05) 0.02 (0, 0.11)
TEfus+ order 3 (1, 5) 3 (1, 5) 3 (1, 6) 3 (1, 6)
PI3K+ count 58 2 59 63 92
PI3K+ time_stop 26 (17, 33) 18 (16, 20) 24 (18, 34) 24 (18, 34) 17 (11, 31)
PI3K+ n_trt 33 (25, 44) 27 (25, 29) 32 (25, 49) 32 (26, 53) 30 (25, 52)
PI3K+ n_control 81 (45, 120) 70 (69, 70) 76 (47, 121) 75 (53, 109) 47 (26, 104)
PI3K+ post_p 0.04 (0.01, 0.13) 0.14 (0.03, 0.25) 0.03 (0.01, 0.17) 0.04 (0, 0.16) 0.06 (0.01, 0.21)
PI3K+ order 3 (1, 5.3) 1.5 (1.1, 1.9) 3 (1.8, 6) 3 (1.2, 5) 2 (1, 4.9)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
all TC1 time 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6)
all TC1 n 18 (14, 20) 1 (1, 3) 1 (1, 1) 0 (0, 2) 3 (1, 4) 2 (1, 3) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.78 (0.6, 0.87) 0.53 (0.52, 0.54) 0.51 (0.51, 0.51) 0.56 (0.53, 0.58) 0.55 (0.52, 0.58) 0.53 (0.52, 0.53) 0.51 (0.5, 0.52) 0.52 (0.51, 0.53) 0.52 (0.52, 0.52) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.54 (0.53, 0.56) 0.51 (0.51, 0.51) 0.51 (0.5, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.053 (0.03, 0.072) 0 (0, 0.07) 0 (0, 0.075) 0 (0, 0) 0 (0, 0.113) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30
all TC2 time 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17) 7 (5, 17)
all TC2 n 12 (5, 26) 2 (0, 5) 0 (0, 2) 1 (0, 3) 3 (1, 7) 1 (0, 4) 2 (0, 5) 2 (0, 4) 2 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 1 (0, 2) 0 (0, 1) 2 (0, 4) 0 (0, 2) 0 (0, 1) 0 (0, 0) 5 (2, 7) 3 (1, 5) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.6 (0.51, 0.85) 0.58 (0.51, 0.77) 0.57 (0.55, 0.75) 0.55 (0.5, 0.75) 0.55 (0.51, 0.69) 0.56 (0.51, 0.66) 0.54 (0.51, 0.7) 0.55 (0.53, 0.78) 0.55 (0.52, 0.79) NA (NA, NA) 0.56 (0.54, 0.7) 0.6 (0.55, 0.74) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) 0.56 (0.52, 0.67) 0.53 (0.5, 0.56) 0.62 (0.54, 0.82) 0.55 (0.5, 0.69) 0.58 (0.51, 0.65) 0.55 (0.51, 0.56) NA (NA, NA) 0.58 (0.52, 0.75) 0.58 (0.52, 0.7) 0.6 (0.53, 0.66) NA (NA, NA) 0.55 (0.53, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.084 (0.047, 0.127) 0 (0, 0.088) 0 (0, 0.163) 0 (0, 0.036) 0 (0, 0.129) 0.053 (0, 0.117) 0 (0, 0.083) 0 (0, 0.059) 0 (0, 0.127) NA (NA, NA) 0 (0, 0.031) 0 (0, 0.112) NA (NA, NA) 0 (0, 0.164) NA (NA, NA) 0 (0, 0.037) 0 (0, 0.176) 0.184 (0, 1.003) 0 (0, 0.018) 0 (0, 0.079) 0 (0, 0) 0.075 (0.075, 0.075) 0 (0, 0.06) 0 (0, 0.062) 0 (0, 0.147) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC3 time 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8) 8 (7, 8)
all TC3 n 7 (6, 8) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (1, 1) 3 (3, 3) 2 (1, 2) 2 (1, 3) 3 (1, 5) 0 (0, 0) 2 (2, 2) 2 (1, 3) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (1, 4) 0 (0, 1) 2 (1, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.55 (0.51, 0.59) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) 0.54 (0.51, 0.58) 0.6 (0.58, 0.62) 0.53 (0.53, 0.53) 0.56 (0.53, 0.59) 0.62 (0.6, 0.65) NA (NA, NA) 0.57 (0.53, 0.62) 0.52 (0.52, 0.52) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.56 (0.55, 0.56) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.101 (0.098, 0.105) 0.672 (0.672, 0.672) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.245 (0.049, 0.441) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.031 (0.006, 0.056) 0 (0, 0) 0.047 (0.009, 0.085) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC4 time 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9)
all TC4 n 8 (4, 12) 2 (0, 2) 0 (0, 0) 1 (0, 2) 2 (1, 3) 1 (0, 3) 1 (0, 2) 1 (0, 5) 4 (3, 7) 0 (0, 0) 3 (1, 5) 1 (0, 4) 0 (0, 0) 0 (0, 1) 0 (0, 0) 2 (1, 2) 0 (0, 0) 0 (0, 0) 1 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 4) 0 (0, 1) 3 (1, 4) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.69 (0.63, 0.72) 0.59 (0.55, 0.64) NA (NA, NA) 0.55 (0.52, 0.55) 0.54 (0.53, 0.56) 0.62 (0.57, 0.63) 0.56 (0.55, 0.58) 0.54 (0.53, 0.56) 0.58 (0.57, 0.68) NA (NA, NA) 0.63 (0.56, 0.8) 0.61 (0.61, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.52, 0.6) 0.55 (0.55, 0.56) 0.64 (0.59, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0 (0, 0.051) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.176) 0 (0, 0.057) 0 (0, 0) 0.082 (0.016, 0.084) 0.049 (0.018, 0.12) NA (NA, NA) 0.031 (0, 0.083) 0.091 (0.018, 0.214) NA (NA, NA) 0.106 (0.021, 0.192) NA (NA, NA) 0.092 (0.022, 0.316) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.333 (0.067, 0.599) 1.307 (1.307, 1.307) NA (NA, NA) 0 (0, 0.052) 0 (0, 0) 0 (0, 0.109) NA (NA, NA) 0.169 (0.034, 0.304) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC5 time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
all TC5 n 4 (2, 6) 4 (4, 5) 0 (0, 0) 3 (2, 4) 0 (0, 1) 2 (1, 4) 0 (0, 1) 6 (4, 7) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.52 (0.5, 0.54) 0.58 (0.53, 0.62) NA (NA, NA) 0.59 (0.54, 0.64) 0.62 (0.62, 0.62) 0.54 (0.52, 0.55) 0.53 (0.53, 0.53) 0.57 (0.53, 0.61) 0.52 (0.52, 0.52) NA (NA, NA) 0.54 (0.54, 0.54) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) 0.54 (0.51, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.081 (0.016, 0.146) 0.082 (0.06, 0.104) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.038 (0.008, 0.068) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 27 27 27 27 27 27 27 27
AR- & TP53- TC1 time 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9)
AR- & TP53- TC1 n 23 (17, 33) 3 (1, 6) 1 (0, 2) 1 (0, 3) 1 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 1)
AR- & TP53- TC1 post_p 0.81 (0.74, 0.94) 0.54 (0.51, 0.72) 0.55 (0.52, 0.61) 0.54 (0.52, 0.6) 0.57 (0.52, 0.66) NA (NA, NA) 0.52 (0.5, 0.6) 0.53 (0.51, 0.58)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.067 (0.042, 0.101) 0.067 (0, 0.123) 0 (0, 0.88) 0 (0, 0.097) 0 (0, 0) NA (NA, NA) 0 (0, 0.053) 0 (0, 0.419)
AR- & TP53- TC2 count 59 59 59 59 59 59 59 59
AR- & TP53- TC2 time 10 (8, 19) 10 (8, 19) 10 (8, 19) 10 (8, 19) 10 (8, 19) 10 (8, 19) 10 (8, 19) 10 (8, 19)
AR- & TP53- TC2 n 23 (18, 36) 3 (1, 5) 1 (0, 3) 1 (0, 4) 3 (1, 7) 0 (0, 0) 1 (0, 3) 0 (0, 2)
AR- & TP53- TC2 post_p 0.85 (0.72, 0.91) 0.59 (0.51, 0.75) 0.55 (0.52, 0.64) 0.59 (0.53, 0.77) 0.62 (0.52, 0.75) NA (NA, NA) 0.57 (0.52, 0.8) 0.54 (0.51, 0.64)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.074 (0.053, 0.094) 0.05 (0, 0.111) 0 (0, 0.07) 0 (0, 0.058) 0.036 (0, 0.102) NA (NA, NA) 0 (0, 0.065) 0 (0, 0.07)
AR- & TP53- TC3 count 8 8 8 8 8 8 8 8
AR- & TP53- TC3 time 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12)
AR- & TP53- TC3 n 14 (11, 21) 4 (2, 4) 0 (0, 1) 0 (0, 3) 7 (4, 8) 0 (0, 0) 1 (0, 4) 1 (0, 2)
AR- & TP53- TC3 post_p 0.79 (0.77, 0.9) 0.54 (0.52, 0.62) 0.54 (0.51, 0.6) 0.55 (0.54, 0.56) 0.72 (0.6, 0.77) NA (NA, NA) 0.55 (0.53, 0.66) 0.57 (0.57, 0.57)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.055 (0.016, 0.069) 0.038 (0, 0.087) 0 (0, 0) 0 (0, 0) 0.057 (0, 0.095) 1.603 (1.603, 1.603) 0.024 (0, 0.241) 0 (0, 0.065)
AR- & TP53- TC4 count 7 7 7 7 7 7 7 7
AR- & TP53- TC4 time 11 (9, 16) 11 (9, 16) 11 (9, 16) 11 (9, 16) 11 (9, 16) 11 (9, 16) 11 (9, 16) 11 (9, 16)
AR- & TP53- TC4 n 13 (12, 26) 3 (1, 6) 0 (0, 0) 3 (1, 4) 5 (4, 11) 0 (0, 0) 2 (1, 6) 2 (1, 3)
AR- & TP53- TC4 post_p 0.83 (0.76, 0.93) 0.58 (0.53, 0.75) 0.54 (0.54, 0.54) 0.56 (0.51, 0.6) 0.59 (0.56, 0.83) NA (NA, NA) 0.57 (0.55, 0.69) 0.54 (0.52, 0.57)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.058 (0.054, 0.072) 0 (0, 0.127) 0 (0, 0) 0 (0, 0.104) 0.059 (0.04, 0.093) NA (NA, NA) 0.084 (0, 0.272) 0.119 (0, 0.868)
AR- & TP53- TC5 count 5 5 5 5 5 5 5 5
AR- & TP53- TC5 time 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17)
AR- & TP53- TC5 n 25 (15, 29) 10 (3, 12) 1 (0, 4) 3 (2, 5) 2 (1, 4) 0 (0, 0) 1 (1, 2) 1 (0, 1)
AR- & TP53- TC5 post_p 0.9 (0.76, 0.92) 0.72 (0.59, 0.74) 0.52 (0.5, 0.57) 0.56 (0.52, 0.61) 0.58 (0.54, 0.71) NA (NA, NA) 0.58 (0.56, 0.63) 0.55 (0.55, 0.55)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.066 (0.062, 0.071) 0.075 (0.049, 0.106) 0.033 (0, 0.114) 0.033 (0.012, 0.129) 0 (0, 0.08) NA (NA, NA) 0 (0, 0) 0.586 (0.117, 0.738)
HRD+ TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
HRD+ TC1 time 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23)
HRD+ TC1 n 18 (18, 18) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.98 (0.98, 0.98) NA (NA, NA) 0.51 (0.51, 0.51) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) 0.58 (0.58, 0.58) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.069 (0.069, 0.069) NA (NA, NA) 0.15 (0.15, 0.15) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 36 36 36 36 36 36 36 36 36 36 36 36 36 36 36 36
HRD+ TC2 time 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34) 29 (23, 34)
HRD+ TC2 n 14 (6, 18) 0 (0, 0) 5 (2, 10) 2 (0, 6) 0 (0, 0) 0 (0, 4) 0 (0, 0) 1 (0, 3) 4 (1, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.79 (0.71, 0.93) NA (NA, NA) 0.83 (0.52, 0.96) 0.61 (0.55, 0.87) NA (NA, NA) 0.55 (0.51, 0.85) NA (NA, NA) 0.6 (0.52, 0.78) 0.7 (0.54, 0.87) NA (NA, NA) 0.57 (0.53, 0.67) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.082 (0.064, 0.109) NA (NA, NA) 0.034 (0, 0.077) 0.03 (0, 0.065) NA (NA, NA) 0.063 (0, 0.128) 0.481 (0.196, 0.767) 0.034 (0, 0.098) 0.058 (0, 0.135) NA (NA, NA) 0 (0, 0.082) NA (NA, NA) 11.816 (2.363, 21.269) NA (NA, NA) 0.089 (0.018, 0.159) 0 (0, 0)
HRD+ TC3 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
HRD+ TC3 time 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30) 21 (19, 30)
HRD+ TC3 n 14 (13, 23) 0 (0, 0) 4 (4, 5) 2 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 0) 2 (1, 2) 2 (1, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1)
HRD+ TC3 post_p 0.88 (0.75, 0.95) NA (NA, NA) 0.56 (0.53, 0.68) 0.57 (0.52, 0.7) NA (NA, NA) 0.61 (0.54, 0.66) NA (NA, NA) 0.53 (0.52, 0.57) 0.75 (0.61, 0.8) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.082 (0.061, 0.103) NA (NA, NA) 0.084 (0.059, 0.13) 0.05 (0.01, 0.125) NA (NA, NA) 0.036 (0, 0.54) NA (NA, NA) 0.051 (0, 0.166) 0.068 (0, 0.085) NA (NA, NA) 0.073 (0.062, 0.148) NA (NA, NA) 0.101 (0.02, 0.181) NA (NA, NA) 0.285 (0.285, 0.285) 0.247 (0.049, 0.445)
HRD+ TC4 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
HRD+ TC4 time 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25) 20 (19, 25)
HRD+ TC4 n 12 (10, 21) 0 (0, 0) 5 (3, 8) 2 (1, 3) 0 (0, 0) 0 (0, 6) 0 (0, 0) 1 (0, 3) 4 (1, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
HRD+ TC4 post_p 0.91 (0.75, 0.95) NA (NA, NA) 0.73 (0.54, 0.82) 0.65 (0.59, 0.67) NA (NA, NA) 0.71 (0.69, 0.73) NA (NA, NA) 0.55 (0.53, 0.58) 0.69 (0.58, 0.78) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.085 (0.047, 0.098) NA (NA, NA) 0.09 (0.063, 0.103) 0.108 (0.015, 0.329) NA (NA, NA) 0.074 (0.053, 0.095) NA (NA, NA) 0 (0, 0.129) 0.078 (0.071, 0.097) NA (NA, NA) 0.078 (0.062, 0.18) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
HRD+ TC5 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
HRD+ TC5 time 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32) 26 (20, 32)
HRD+ TC5 n 12 (11, 16) 0 (0, 0) 6 (4, 8) 0 (0, 4) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 2) 5 (2, 6) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.81 (0.74, 0.88) NA (NA, NA) 0.68 (0.57, 0.78) 0.64 (0.61, 0.69) NA (NA, NA) 0.6 (0.57, 0.63) NA (NA, NA) 0.58 (0.52, 0.64) 0.67 (0.53, 0.76) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.066 (0.062, 0.093) NA (NA, NA) 0.064 (0.047, 0.084) 0 (0, 0.036) NA (NA, NA) 0 (0, 0.039) NA (NA, NA) 0.048 (0, 0.104) 0.081 (0.035, 0.126) NA (NA, NA) 0.136 (0.037, 0.188) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TP53+ TC2 count 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60
TP53+ TC2 time 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28)
TP53+ TC2 n 5 (3, 14) 4 (2, 10) 2 (1, 5) 4 (3, 11) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 0) 8 (5, 13) 4 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.71 (0.55, 0.85) 0.7 (0.54, 0.84) 0.6 (0.53, 0.75) 0.73 (0.59, 0.91) NA (NA, NA) 0.55 (0.54, 0.6) NA (NA, NA) 0.55 (0.52, 0.62) 0.53 (0.52, 0.58) NA (NA, NA) 0.75 (0.61, 0.94) 0.74 (0.55, 0.94) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.074 (0.032, 0.132) 0.069 (0.011, 0.118) 0.023 (0, 0.06) 0.03 (0, 0.06) NA (NA, NA) 0 (0, 0.115) NA (NA, NA) 0 (0, 0.152) 0.056 (0, 0.28) 0 (0, 0) 0.034 (0, 0.06) 0.027 (0, 0.069) 0 (0, 0) 0.179 (0.179, 0.179) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TP53+ TC3 time 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16)
TP53+ TC3 n 7 (5, 9) 6 (3, 8) 2 (1, 4) 2 (2, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 2 (0, 4) 0 (0, 0) 0 (0, 0) 4 (3, 4) 2 (0, 4) 2 (0, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.81 (0.73, 0.9) 0.78 (0.68, 0.88) 0.54 (0.53, 0.55) 0.59 (0.55, 0.63) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) 0.6 (0.59, 0.61) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.017 (0.003, 0.031) 0.041 (0.023, 0.058) 0.034 (0.007, 0.062) 0.028 (0.006, 0.05) NA (NA, NA) 0.163 (0.163, 0.163) NA (NA, NA) 0.07 (0.07, 0.07) NA (NA, NA) NA (NA, NA) 0.076 (0.064, 0.087) 0.072 (0.072, 0.072) 0.181 (0.181, 0.181) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TP53+ TC5 time 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12)
TP53+ TC5 n 2 (1, 4) 8 (6, 10) 0 (0, 1) 5 (3, 7) 0 (0, 0) 2 (1, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 5 (3, 7) 4 (3, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.54 (0.52, 0.55) 0.81 (0.71, 0.9) 0.52 (0.52, 0.52) 0.67 (0.6, 0.75) NA (NA, NA) 0.59 (0.56, 0.62) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.68 (0.61, 0.75) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.026 (0.005, 0.047) 0.03 (0.006, 0.054) 0 (0, 0) 0.069 (0.06, 0.078) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.084 (0.074, 0.095) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 228 228 228 228 228 228 228 228 228 228 228 228 228 228 228 228
TEfus+ TC2 time 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31)
TEfus+ TC2 n 2 (0, 4) 3 (1, 10) 3 (1, 7) 6 (2, 15) 3 (0, 8) 1 (0, 4) 0 (0, 0) 1 (0, 3) 3 (1, 7) 1 (0, 3) 10 (5, 18) 5 (2, 13) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.6 (0.52, 0.81) 0.7 (0.53, 0.92) 0.62 (0.52, 0.83) 0.77 (0.57, 0.97) 0.67 (0.54, 0.91) 0.59 (0.52, 0.8) NA (NA, NA) 0.57 (0.51, 0.66) 0.65 (0.54, 0.89) 0.58 (0.51, 0.73) 0.78 (0.65, 0.97) 0.77 (0.55, 0.96) 0.58 (0.52, 0.64) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0 (0, 0.09) 0.02 (0, 0.081) 0.023 (0, 0.072) 0.029 (0, 0.067) 0.013 (0, 0.08) 0 (0, 0.088) 0.419 (0.084, 0.755) 0 (0, 0.128) 0.026 (0, 0.077) 0 (0, 0.09) 0.033 (0, 0.064) 0.032 (0, 0.072) 0 (0, 0.083) 0 (0, 1.494) 1.249 (0.391, 2.107) 0 (0, 0.281)
PI3K+ TC2 count 63 63 63 63 63 63 63 63 63 63 63 63 63 63 63 63
PI3K+ TC2 time 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28) 20 (13, 28)
PI3K+ TC2 n 6 (2, 16) 3 (1, 9) 6 (3, 12) 6 (2, 13) 0 (0, 0) 1 (0, 4) 1 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 4) 0 (0, 0) 5 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.72 (0.53, 0.89) 0.7 (0.56, 0.89) 0.73 (0.54, 0.87) 0.8 (0.62, 0.96) NA (NA, NA) 0.61 (0.54, 0.69) 0.56 (0.51, 0.67) 0.6 (0.52, 0.74) 0.57 (0.5, 0.72) 0.56 (0.51, 0.72) NA (NA, NA) 0.74 (0.58, 0.94) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.078 (0.031, 0.114) 0.027 (0, 0.06) 0.073 (0.002, 0.12) 0.035 (0, 0.053) 0.133 (0.133, 0.133) 0 (0, 0.064) 0.047 (0, 0.262) 0 (0, 0.116) 0.11 (0, 0.739) 0.022 (0, 0.096) 0.244 (0.109, 0.379) 0.038 (0, 0.071) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.176 (0.035, 0.316)
PI3K+ TC3 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
PI3K+ TC3 time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
PI3K+ TC3 n 5 (5, 5) 3 (3, 3) 10 (10, 10) 2 (2, 2) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.73 (0.73, 0.73) 0.65 (0.65, 0.65) 0.89 (0.89, 0.89) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.59 (0.59, 0.59) 0.52 (0.52, 0.52) NA (NA, NA) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.042 (0.042, 0.042) 0 (0, 0) 0.021 (0.021, 0.021) 0.062 (0.062, 0.062) NA (NA, NA) 0.171 (0.171, 0.171) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.115 (0.115, 0.115) NA (NA, NA) 0.082 (0.082, 0.082) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
PI3K+ TC5 time 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14) 14 (10, 14)
PI3K+ TC5 n 10 (6, 12) 4 (4, 4) 4 (3, 9) 4 (3, 5) 0 (0, 0) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 1 (0, 3) 0 (0, 1) 3 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.75 (0.62, 0.83) 0.54 (0.51, 0.57) 0.64 (0.53, 0.86) 0.57 (0.51, 0.77) NA (NA, NA) NA (NA, NA) 0.64 (0.59, 0.68) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) 0.56 (0.52, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.038 (0.03, 0.091) 0.073 (0.048, 0.112) 0.066 (0.052, 0.129) 0.083 (0.054, 0.132) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.22 (0.22, 0.22) 0.043 (0.009, 0.196) 0 (0, 0) 0.025 (0, 0.058) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
all TC1 time 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11) 4 (3, 11)
all TC1 n 17 (14, 23) 3 (1, 5) 0 (0, 3) 1 (0, 2) 2 (1, 4) 1 (0, 4) 0 (0, 1) 0 (0, 4) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 3) 0 (0, 3) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.31 (0.09, 0.44) 0.41 (0.34, 0.47) 0.48 (0.48, 0.49) 0.41 (0.29, 0.44) 0.45 (0.39, 0.48) 0.42 (0.33, 0.47) 0.41 (0.35, 0.48) 0.46 (0.3, 0.5) 0.3 (0.28, 0.32) NA (NA, NA) 0.5 (0.5, 0.5) 0.36 (0.36, 0.36) NA (NA, NA) 0.45 (0.45, 0.45) NA (NA, NA) 0.45 (0.45, 0.45) 0.44 (0.41, 0.47) 0.43 (0.42, 0.44) 0.39 (0.31, 0.47) 0.46 (0.43, 0.48) 0.42 (0.42, 0.42) NA (NA, NA) 0.43 (0.31, 0.46) 0.39 (0.34, 0.44) 0.31 (0.31, 0.31) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.152 (0.096, 0.197) 0.161 (0.012, 0.262) 0.155 (0.036, 0.39) 0.312 (0.104, 10.848) 0.222 (0.012, 0.462) 0.153 (0.05, 2.087) 0 (0, 1.014) 0.116 (0, 0.336) 0.231 (0.176, 0.429) NA (NA, NA) 0.04 (0.008, 0.071) 0.497 (0.497, 0.497) NA (NA, NA) 0.205 (0.041, 0.369) NA (NA, NA) 0.178 (0.178, 0.178) 0.205 (0, 0.857) 0.909 (0.418, 1) 0 (0, 0.163) 0 (0, 0.463) 0.117 (0.023, 1.04) NA (NA, NA) 0.224 (0.08, 1.308) 0.349 (0.047, 0.486) 0.192 (0.15, 0.234) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC3 time 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28)
all TC3 n 10 (7, 17) 6 (2, 11) 1 (0, 2) 2 (1, 4) 5 (2, 6) 4 (3, 4) 2 (0, 3) 5 (2, 6) 4 (3, 8) 0 (0, 1) 2 (0, 8) 3 (1, 5) 0 (0, 0) 1 (0, 1) 0 (0, 0) 2 (0, 3) 2 (0, 4) 0 (0, 0) 2 (0, 3) 0 (0, 1) 0 (0, 1) 0 (0, 0) 3 (2, 5) 1 (0, 4) 2 (1, 5) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0)
all TC3 post_p 0.38 (0.22, 0.4) 0.3 (0.16, 0.43) 0.4 (0.33, 0.4) 0.39 (0.32, 0.46) 0.32 (0.16, 0.37) 0.41 (0.32, 0.49) 0.42 (0.37, 0.47) 0.43 (0.37, 0.49) 0.33 (0.23, 0.45) NA (NA, NA) 0.44 (0.43, 0.46) 0.39 (0.27, 0.43) NA (NA, NA) 0.46 (0.45, 0.48) NA (NA, NA) 0.45 (0.45, 0.45) 0.4 (0.22, 0.46) NA (NA, NA) 0.38 (0.34, 0.48) 0.4 (0.4, 0.4) 0.45 (0.45, 0.45) NA (NA, NA) 0.42 (0.26, 0.46) 0.39 (0.26, 0.4) 0.37 (0.36, 0.45) NA (NA, NA) 0.44 (0.44, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.142 (0.134, 0.168) 0.258 (0.161, 0.357) 0.305 (0.127, 0.401) 0.166 (0.113, 0.354) 0.142 (0.104, 0.261) 0.177 (0.13, 0.229) 0.229 (0.129, 0.836) 0.134 (0.1, 0.461) 0.293 (0.134, 0.407) 0.122 (0.122, 0.122) 0.215 (0.112, 0.217) 0.156 (0.092, 0.349) NA (NA, NA) 0.909 (0.182, 10.6) NA (NA, NA) 0.135 (0.118, 0.317) 0.355 (0.149, 0.625) NA (NA, NA) 0.136 (0.084, 0.412) 0.099 (0.099, 0.099) 2.377 (2.377, 2.377) NA (NA, NA) 0.151 (0.144, 0.208) 0.28 (0.17, 5.538) 0.163 (0.141, 0.206) NA (NA, NA) 0.9 (0.307, 1.493) 0.311 (0.311, 0.311) NA (NA, NA) NA (NA, NA) 0.609 (0.609, 0.609) NA (NA, NA)
all TC5 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC5 time 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25) 22 (12, 25)
all TC5 n 15 (5, 47) 5 (3, 10) 0 (0, 3) 5 (1, 10) 4 (2, 6) 4 (2, 6) 1 (0, 5) 5 (4, 8) 4 (1, 10) 0 (0, 0) 2 (0, 4) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 1 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 5 (3, 7) 4 (3, 7) 1 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.31 (0.14, 0.35) 0.34 (0.13, 0.38) 0.29 (0.19, 0.39) 0.4 (0.27, 0.45) 0.44 (0.24, 0.45) 0.26 (0.21, 0.29) 0.4 (0.31, 0.42) 0.16 (0.11, 0.2) 0.36 (0.23, 0.4) NA (NA, NA) 0.31 (0.27, 0.39) 0.5 (0.49, 0.5) NA (NA, NA) 0.4 (0.4, 0.4) NA (NA, NA) 0.39 (0.39, 0.39) 0.49 (0.48, 0.49) NA (NA, NA) 0.36 (0.27, 0.46) NA (NA, NA) 0.4 (0.4, 0.4) NA (NA, NA) 0.28 (0.19, 0.3) 0.39 (0.37, 0.47) 0.42 (0.39, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.144 (0.119, 0.294) 0.158 (0.121, 0.543) 0.31 (0.178, 0.443) 0.147 (0.098, 0.267) 0.164 (0.128, 0.438) 0.205 (0.169, 0.767) 1.415 (0.127, 6.038) 0.182 (0.072, 0.287) 0.152 (0.119, 0.233) NA (NA, NA) 0.206 (0.134, 0.295) 0.037 (0.007, 0.066) NA (NA, NA) 0.229 (0.229, 0.229) NA (NA, NA) 0.291 (0.131, 0.452) 0.099 (0.076, 0.652) NA (NA, NA) 0.128 (0.091, 0.386) 0.308 (0.062, 0.554) 0.361 (0.361, 0.361) NA (NA, NA) 0.141 (0.048, 0.163) 0.156 (0.094, 0.502) 0.098 (0.02, 0.209) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.775 (0.775, 0.775) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 125 125 125 125 125 125 125 125
AR- & TP53- TC1 time 13 (6, 30) 13 (6, 30) 13 (6, 30) 13 (6, 30) 13 (6, 30) 13 (6, 30) 13 (6, 30) 13 (6, 30)
AR- & TP53- TC1 n 24 (16, 46) 5 (2, 11) 1 (0, 4) 3 (0, 6) 3 (0, 9) 0 (0, 0) 1 (0, 5) 1 (0, 2)
AR- & TP53- TC1 post_p 0.32 (0.11, 0.45) 0.38 (0.19, 0.48) 0.44 (0.31, 0.49) 0.41 (0.29, 0.47) 0.42 (0.17, 0.49) NA (NA, NA) 0.42 (0.27, 0.49) 0.42 (0.32, 0.49)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.126 (0.102, 0.172) 0.153 (0.102, 0.44) 0.172 (0, 0.798) 0.145 (0.092, 0.494) 0.172 (0.096, 0.656) 0.463 (0.463, 0.463) 0.159 (0.075, 0.858) 0.21 (0, 1.105)
AR- & TP53- TC2 count 8 8 8 8 8 8 8 8
AR- & TP53- TC2 time 12 (9, 18) 12 (9, 18) 12 (9, 18) 12 (9, 18) 12 (9, 18) 12 (9, 18) 12 (9, 18) 12 (9, 18)
AR- & TP53- TC2 n 15 (10, 29) 4 (2, 7) 0 (0, 2) 1 (0, 2) 4 (4, 5) 0 (0, 0) 1 (0, 3) 1 (0, 1)
AR- & TP53- TC2 post_p 0.29 (0.08, 0.46) 0.4 (0.11, 0.46) 0.44 (0.41, 0.48) 0.44 (0.4, 0.48) 0.48 (0.37, 0.5) NA (NA, NA) 0.46 (0.4, 0.48) 0.39 (0.31, 0.45)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.146 (0.112, 0.189) 0.215 (0.106, 0.309) 0.104 (0.031, 0.115) 0.111 (0.036, 0.612) 0.147 (0.114, 0.225) NA (NA, NA) 0.157 (0.04, 0.263) 0.11 (0, 0.565)
AR- & TP53- TC3 count 121 121 121 121 121 121 121 121
AR- & TP53- TC3 time 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33)
AR- & TP53- TC3 n 20 (8, 52) 6 (3, 13) 1 (0, 3) 3 (1, 8) 7 (3, 13) 0 (0, 0) 4 (1, 9) 2 (0, 4)
AR- & TP53- TC3 post_p 0.31 (0.09, 0.46) 0.38 (0.17, 0.48) 0.42 (0.3, 0.49) 0.4 (0.22, 0.49) 0.37 (0.18, 0.48) NA (NA, NA) 0.37 (0.16, 0.49) 0.41 (0.31, 0.48)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.135 (0.109, 0.228) 0.158 (0.114, 0.345) 0.174 (0.076, 0.526) 0.156 (0.084, 0.566) 0.153 (0.11, 0.303) 0 (0, 0) 0.143 (0.076, 0.482) 0.172 (0.085, 0.473)
AR- & TP53- TC4 count 124 124 124 124 124 124 124 124
AR- & TP53- TC4 time 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31)
AR- & TP53- TC4 n 21 (8, 52) 6 (2, 12) 1 (0, 3) 3 (1, 8) 7 (3, 12) 0 (0, 0) 4 (2, 8) 2 (1, 5)
AR- & TP53- TC4 post_p 0.32 (0.1, 0.48) 0.34 (0.17, 0.47) 0.42 (0.31, 0.49) 0.38 (0.21, 0.48) 0.35 (0.19, 0.47) NA (NA, NA) 0.38 (0.22, 0.48) 0.42 (0.28, 0.49)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.134 (0.107, 0.192) 0.162 (0.105, 0.404) 0.176 (0.063, 0.721) 0.178 (0.081, 0.59) 0.15 (0.104, 0.31) 0.134 (0.027, 0.545) 0.146 (0.08, 0.375) 0.147 (0.065, 0.489)
AR- & TP53- TC5 count 100 100 100 100 100 100 100 100
AR- & TP53- TC5 time 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33)
AR- & TP53- TC5 n 17 (7, 41) 8 (4, 16) 1 (0, 3) 4 (2, 7) 4 (2, 11) 0 (0, 0) 3 (0, 7) 1 (0, 3)
AR- & TP53- TC5 post_p 0.33 (0.1, 0.46) 0.32 (0.18, 0.47) 0.42 (0.26, 0.48) 0.37 (0.22, 0.46) 0.36 (0.21, 0.48) NA (NA, NA) 0.38 (0.2, 0.49) 0.44 (0.32, 0.49)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.132 (0.109, 0.224) 0.148 (0.101, 0.269) 0.19 (0.059, 0.636) 0.141 (0.092, 0.312) 0.175 (0.11, 0.406) 7.972 (7.972, 7.972) 0.159 (0.084, 0.451) 0.14 (0.067, 0.623)
HRD+ TC1 count 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23
HRD+ TC1 time 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35)
HRD+ TC1 n 11 (5, 18) 0 (0, 1) 5 (3, 9) 2 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 2) 4 (2, 8) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.38 (0.21, 0.49) NA (NA, NA) 0.34 (0.18, 0.47) 0.4 (0.22, 0.49) NA (NA, NA) 0.38 (0.29, 0.45) NA (NA, NA) 0.42 (0.3, 0.48) 0.42 (0.23, 0.48) NA (NA, NA) 0.46 (0.4, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.131 (0.104, 0.236) 0.091 (0.064, 1.086) 0.121 (0.089, 0.31) 0.161 (0.082, 0.499) 0 (0, 0) 0.426 (0.169, 1.056) NA (NA, NA) 0.186 (0.093, 0.53) 0.145 (0.108, 0.384) NA (NA, NA) 0.041 (0, 0.222) 0.279 (0.279, 0.279) 0.214 (0.043, 0.486) 0.316 (0.316, 0.316) NA (NA, NA) 0.207 (0.207, 0.207)
HRD+ TC3 count 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41
HRD+ TC3 time 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35) 29 (24, 35)
HRD+ TC3 n 12 (5, 20) 0 (0, 0) 6 (3, 12) 2 (0, 5) 0 (0, 0) 1 (0, 4) 0 (0, 0) 2 (0, 4) 4 (2, 6) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.4 (0.23, 0.49) NA (NA, NA) 0.33 (0.16, 0.46) 0.39 (0.32, 0.47) NA (NA, NA) 0.44 (0.35, 0.48) NA (NA, NA) 0.41 (0.31, 0.48) 0.38 (0.25, 0.48) NA (NA, NA) 0.42 (0.37, 0.46) NA (NA, NA) 0.45 (0.45, 0.45) NA (NA, NA) 0.38 (0.38, 0.38) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.135 (0.104, 0.25) 0.122 (0.122, 0.122) 0.123 (0.084, 0.222) 0.141 (0.083, 0.389) 0 (0, 0) 0.164 (0.091, 0.552) NA (NA, NA) 0.145 (0.086, 0.286) 0.148 (0.104, 0.279) 0.239 (0.239, 0.239) 0.21 (0.074, 0.656) 0.104 (0.104, 0.104) 0.09 (0, 1.623) 0.095 (0.065, 0.676) 0.262 (0.262, 0.262) 0 (0, 1.086)
HRD+ TC4 count 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52
HRD+ TC4 time 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36) 29 (21, 36)
HRD+ TC4 n 11 (5, 17) 0 (0, 0) 5 (2, 10) 2 (1, 5) 0 (0, 0) 2 (0, 4) 0 (0, 0) 2 (0, 4) 4 (2, 6) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.37 (0.11, 0.47) NA (NA, NA) 0.36 (0.2, 0.45) 0.43 (0.26, 0.48) 0.49 (0.49, 0.49) 0.42 (0.31, 0.48) NA (NA, NA) 0.41 (0.26, 0.48) 0.38 (0.25, 0.47) NA (NA, NA) 0.46 (0.4, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.131 (0.102, 0.285) 0.648 (0.648, 0.648) 0.126 (0.08, 0.287) 0.171 (0.074, 0.42) 0.052 (0, 0.122) 0.162 (0.071, 0.417) NA (NA, NA) 0.169 (0.07, 0.807) 0.175 (0.094, 0.439) 0.676 (0.135, 1.217) 0.107 (0, 0.812) 0.072 (0.07, 1.738) 0 (0, 0) 0.072 (0.014, 0.129) 0.268 (0.268, 0.268) NA (NA, NA)
HRD+ TC5 count 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28
HRD+ TC5 time 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35) 30 (26, 35)
HRD+ TC5 n 14 (7, 19) 0 (0, 0) 4 (2, 9) 2 (0, 4) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 3) 4 (1, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.37 (0.19, 0.48) NA (NA, NA) 0.33 (0.18, 0.46) 0.38 (0.23, 0.48) NA (NA, NA) 0.43 (0.32, 0.48) NA (NA, NA) 0.4 (0.3, 0.45) 0.33 (0.23, 0.48) NA (NA, NA) 0.41 (0.36, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.127 (0.106, 0.177) 7.769 (7.769, 7.769) 0.17 (0.094, 0.603) 0.181 (0.074, 0.431) NA (NA, NA) 0.246 (0.063, 3.778) 10.851 (10.851, 10.851) 0.212 (0.095, 0.389) 0.21 (0.113, 0.431) 0.195 (0.195, 0.195) 0.211 (0.085, 1.007) NA (NA, NA) 0.414 (0.274, 0.555) 0.065 (0.065, 0.065) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
TP53+ TC1 time 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34)
TP53+ TC1 n 8 (4, 16) 6 (3, 13) 3 (1, 5) 5 (2, 11) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 5 (3, 10) 4 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.34 (0.12, 0.49) 0.35 (0.17, 0.48) 0.41 (0.25, 0.48) 0.35 (0.17, 0.48) NA (NA, NA) 0.43 (0.37, 0.48) NA (NA, NA) 0.42 (0.32, 0.49) 0.46 (0.4, 0.48) NA (NA, NA) 0.31 (0.13, 0.45) 0.35 (0.17, 0.46) 0.49 (0.43, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.144 (0.103, 0.271) 0.158 (0.109, 0.298) 0.16 (0.073, 0.603) 0.141 (0.09, 0.313) NA (NA, NA) 0.204 (0.088, 0.764) 0.079 (0.079, 0.079) 0.209 (0, 0.666) 0.21 (0, 0.336) 0.199 (0.043, 0.375) 0.133 (0.085, 0.274) 0.158 (0.091, 0.327) 0.281 (0, 6.122) 0 (0, 0) 1.644 (1.644, 1.644) 0 (0, 0)
TP53+ TC3 count 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87
TP53+ TC3 time 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34)
TP53+ TC3 n 5 (3, 11) 5 (2, 11) 2 (0, 4) 4 (2, 10) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 4 (2, 8) 4 (2, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.31 (0.15, 0.47) 0.35 (0.19, 0.48) 0.39 (0.23, 0.47) 0.32 (0.16, 0.46) NA (NA, NA) 0.43 (0.35, 0.48) NA (NA, NA) 0.42 (0.34, 0.48) 0.45 (0.39, 0.49) NA (NA, NA) 0.33 (0.14, 0.47) 0.35 (0.18, 0.48) 0.44 (0.42, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.17 (0.111, 0.469) 0.166 (0.117, 0.329) 0.2 (0.078, 0.579) 0.141 (0.09, 0.392) 0.126 (0.025, 0.128) 0.174 (0.073, 0.886) 0 (0, 0) 0.199 (0.093, 0.759) 0.212 (0, 0.794) 0.138 (0.108, 0.21) 0.139 (0.085, 0.274) 0.148 (0.09, 0.313) 0.126 (0.004, 1.162) 0.1 (0, 0.433) 0.121 (0.017, 0.565) 0.047 (0, 0.848)
TP53+ TC4 count 77 77 77 77 77 77 77 77 77 77 77 77 77 77 77 77
TP53+ TC4 time 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34) 27 (17, 34)
TP53+ TC4 n 6 (3, 11) 5 (3, 12) 2 (0, 5) 4 (2, 14) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 1 (0, 2) 0 (0, 0) 6 (3, 11) 5 (2, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.3 (0.1, 0.46) 0.35 (0.17, 0.46) 0.42 (0.31, 0.49) 0.35 (0.16, 0.46) NA (NA, NA) 0.44 (0.34, 0.49) NA (NA, NA) 0.42 (0.31, 0.47) 0.45 (0.37, 0.48) NA (NA, NA) 0.3 (0.16, 0.47) 0.36 (0.18, 0.47) NA (NA, NA) 0.5 (0.5, 0.5) 0.47 (0.47, 0.47) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.171 (0.113, 0.462) 0.16 (0.119, 0.335) 0.143 (0.079, 0.354) 0.149 (0.085, 0.389) 0.124 (0.124, 0.124) 0.184 (0, 0.645) 0.098 (0.02, 0.177) 0.251 (0.089, 0.865) 0.167 (0, 0.424) 0 (0, 0) 0.136 (0.083, 0.355) 0.146 (0.086, 0.266) 0.101 (0, 0.182) 0.348 (0.184, 0.512) 0.109 (0.022, 0.196) NA (NA, NA)
TP53+ TC5 count 109 109 109 109 109 109 109 109 109 109 109 109 109 109 109 109
TP53+ TC5 time 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32)
TP53+ TC5 n 5 (3, 11) 7 (4, 13) 2 (0, 5) 6 (3, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 0) 5 (2, 9) 5 (2, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.35 (0.17, 0.46) 0.34 (0.15, 0.48) 0.41 (0.29, 0.48) 0.3 (0.13, 0.47) NA (NA, NA) 0.44 (0.37, 0.5) NA (NA, NA) 0.44 (0.34, 0.48) 0.46 (0.4, 0.48) NA (NA, NA) 0.32 (0.16, 0.48) 0.37 (0.18, 0.47) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.166 (0.111, 0.303) 0.147 (0.093, 0.267) 0.168 (0.065, 0.481) 0.142 (0.086, 0.227) 0.402 (0.08, 0.723) 0.163 (0.041, 0.47) 0 (0, 0) 0.149 (0, 0.609) 0.22 (0.065, 0.952) 0 (0, 0) 0.154 (0.083, 0.436) 0.14 (0.078, 0.347) 0.245 (0, 1.737) 0.28 (0.108, 0.451) 0 (0, 0.319) 0.614 (0.134, 3.205)
TEfus+ TC1 count 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92
TEfus+ TC1 time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
TEfus+ TC1 n 2 (0, 4) 3 (1, 8) 3 (0, 5) 5 (2, 10) 3 (0, 7) 1 (0, 4) 0 (0, 0) 1 (0, 2) 2 (1, 5) 1 (0, 3) 5 (3, 10) 4 (2, 11) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.4 (0.23, 0.48) 0.37 (0.18, 0.48) 0.39 (0.25, 0.47) 0.31 (0.15, 0.46) 0.38 (0.24, 0.48) 0.41 (0.31, 0.47) NA (NA, NA) 0.43 (0.37, 0.48) 0.38 (0.24, 0.48) 0.43 (0.32, 0.48) 0.31 (0.13, 0.44) 0.33 (0.15, 0.47) 0.45 (0.36, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.186 (0.075, 0.824) 0.14 (0.087, 0.474) 0.144 (0.088, 0.431) 0.144 (0.087, 0.334) 0.161 (0.096, 0.48) 0.168 (0.076, 0.496) 0.114 (0.086, 0.142) 0.188 (0.07, 0.591) 0.154 (0.077, 0.511) 0.195 (0.076, 0.589) 0.144 (0.092, 0.349) 0.136 (0.08, 0.46) 0.165 (0, 0.842) 0 (0, 0) 0 (0, 0) 0.063 (0.013, 0.37)
TEfus+ TC3 count 104 104 104 104 104 104 104 104 104 104 104 104 104 104 104 104
TEfus+ TC3 time 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33)
TEfus+ TC3 n 2 (0, 3) 3 (1, 7) 2 (0, 4) 4 (2, 10) 5 (2, 10) 2 (0, 4) 0 (0, 0) 1 (0, 3) 2 (1, 5) 1 (0, 3) 5 (2, 11) 4 (2, 9) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.41 (0.32, 0.49) 0.37 (0.21, 0.46) 0.38 (0.25, 0.47) 0.35 (0.16, 0.47) 0.35 (0.13, 0.48) 0.4 (0.28, 0.48) NA (NA, NA) 0.42 (0.31, 0.48) 0.41 (0.27, 0.47) 0.42 (0.33, 0.48) 0.32 (0.13, 0.47) 0.33 (0.2, 0.45) 0.44 (0.4, 0.49) 0.45 (0.45, 0.45) 0.41 (0.41, 0.41) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.164 (0.065, 0.449) 0.158 (0.092, 0.529) 0.17 (0.09, 0.459) 0.15 (0.092, 0.353) 0.134 (0.088, 0.347) 0.16 (0.088, 0.576) 0.28 (0.056, 0.505) 0.171 (0.076, 0.795) 0.164 (0.075, 0.626) 0.135 (0.047, 0.889) 0.137 (0.085, 0.283) 0.15 (0.094, 0.344) 0.159 (0, 0.845) 0.228 (0.101, 0.567) 0.162 (0.022, 0.506) 0.124 (0.063, 0.185)
TEfus+ TC4 count 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90
TEfus+ TC4 time 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35)
TEfus+ TC4 n 2 (0, 5) 4 (1, 9) 2 (0, 5) 5 (2, 11) 5 (2, 9) 3 (1, 5) 0 (0, 0) 2 (0, 4) 2 (1, 5) 1 (0, 4) 6 (2, 12) 4 (2, 10) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.41 (0.29, 0.49) 0.35 (0.18, 0.48) 0.41 (0.22, 0.48) 0.3 (0.15, 0.45) 0.3 (0.13, 0.45) 0.4 (0.25, 0.48) NA (NA, NA) 0.41 (0.28, 0.49) 0.38 (0.21, 0.46) 0.38 (0.29, 0.49) 0.26 (0.13, 0.43) 0.31 (0.15, 0.45) 0.44 (0.37, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.173 (0.084, 1.058) 0.166 (0.085, 0.591) 0.146 (0.088, 0.423) 0.152 (0.09, 0.471) 0.148 (0.086, 0.35) 0.156 (0.08, 0.326) 0 (0, 0) 0.174 (0.073, 0.609) 0.161 (0.091, 0.687) 0.191 (0.075, 0.886) 0.138 (0.091, 0.268) 0.154 (0.09, 0.35) 0.179 (0.045, 0.64) 0 (0, 0) 0.169 (0.034, 0.648) 0 (0, 0)
TEfus+ TC5 count 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92
TEfus+ TC5 time 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35) 27 (16, 35)
TEfus+ TC5 n 2 (0, 4) 5 (2, 9) 2 (0, 5) 6 (3, 11) 4 (1, 8) 1 (0, 3) 0 (0, 0) 1 (0, 2) 2 (0, 5) 1 (0, 4) 4 (2, 9) 4 (2, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.4 (0.23, 0.49) 0.35 (0.18, 0.48) 0.42 (0.29, 0.49) 0.29 (0.13, 0.45) 0.39 (0.18, 0.48) 0.42 (0.29, 0.47) NA (NA, NA) 0.43 (0.32, 0.48) 0.4 (0.24, 0.48) 0.43 (0.3, 0.49) 0.34 (0.14, 0.46) 0.34 (0.17, 0.47) 0.46 (0.42, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.186 (0.068, 0.649) 0.148 (0.086, 0.29) 0.149 (0.068, 0.594) 0.13 (0.088, 0.27) 0.139 (0.087, 0.352) 0.181 (0.079, 0.579) NA (NA, NA) 0.148 (0, 1.015) 0.18 (0.061, 0.691) 0.184 (0.058, 0.603) 0.138 (0.093, 0.287) 0.132 (0.079, 0.247) 0.087 (0, 0.268) 0.325 (0.325, 0.325) 0.073 (0.015, 0.131) 0.151 (0.129, 0.172)
PI3K+ TC1 count 58 58 58 58 58 58 58 58 58 58 58 58 58 58 58 58
PI3K+ TC1 time 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33) 26 (17, 33)
PI3K+ TC1 n 7 (3, 13) 3 (0, 6) 6 (3, 12) 6 (2, 10) 0 (0, 0) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 2) 2 (0, 4) 0 (0, 0) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.32 (0.18, 0.48) 0.36 (0.21, 0.48) 0.37 (0.18, 0.48) 0.34 (0.16, 0.48) NA (NA, NA) 0.43 (0.32, 0.48) 0.44 (0.35, 0.49) 0.4 (0.3, 0.48) 0.45 (0.35, 0.49) 0.43 (0.36, 0.48) NA (NA, NA) 0.31 (0.16, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.143 (0.109, 0.301) 0.133 (0.079, 0.387) 0.151 (0.111, 0.288) 0.139 (0.087, 0.544) 0.024 (0.005, 0.042) 0.206 (0.092, 0.603) 0.184 (0.085, 0.978) 0.192 (0.065, 0.65) 0.199 (0.008, 0.498) 0.139 (0.071, 0.483) 0.041 (0.008, 0.246) 0.165 (0.095, 0.322) 0.139 (0.057, 0.146) NA (NA, NA) 0.063 (0.013, 0.113) 0.07 (0.07, 0.071)
PI3K+ TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC2 time 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20)
PI3K+ TC2 n 6 (5, 6) 6 (4, 8) 5 (5, 5) 2 (1, 4) 0 (0, 0) 0 (0, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 6 (6, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.18 (0.06, 0.3) 0.44 (0.41, 0.46) 0.34 (0.27, 0.42) 0.36 (0.33, 0.4) NA (NA, NA) 0.31 (0.31, 0.31) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.47 (0.45, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.325 (0.18, 0.47) 0.095 (0.072, 0.118) 0.198 (0.163, 0.233) 2.172 (0.523, 3.822) NA (NA, NA) 0.54 (0.54, 0.54) 0.347 (0.249, 0.445) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.353 (0.353, 0.353) 0.09 (0.073, 0.106) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 count 59 59 59 59 59 59 59 59 59 59 59 59 59 59 59 59
PI3K+ TC3 time 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34)
PI3K+ TC3 n 6 (3, 17) 3 (1, 8) 6 (3, 11) 5 (3, 10) 0 (0, 0) 1 (0, 4) 1 (0, 3) 1 (0, 3) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
PI3K+ TC3 post_p 0.34 (0.17, 0.45) 0.36 (0.22, 0.46) 0.33 (0.17, 0.46) 0.35 (0.2, 0.48) NA (NA, NA) 0.41 (0.28, 0.5) 0.41 (0.32, 0.46) 0.44 (0.32, 0.47) 0.42 (0.39, 0.49) 0.42 (0.32, 0.47) NA (NA, NA) 0.31 (0.16, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.152 (0.113, 0.261) 0.16 (0.086, 0.583) 0.163 (0.112, 0.351) 0.123 (0.095, 0.216) 0.122 (0.122, 0.122) 0.175 (0.07, 0.537) 0.155 (0.037, 0.909) 0.169 (0.044, 0.724) 0.245 (0.067, 1.215) 0.172 (0.07, 1.069) 0.114 (0.023, 0.206) 0.151 (0.09, 0.408) 0.117 (0.021, 0.217) 0.311 (0.141, 0.329) 0.068 (0.014, 0.085) 0.083 (0, 0.873)
PI3K+ TC4 count 63 63 63 63 63 63 63 63 63 63 63 63 63 63 63 63
PI3K+ TC4 time 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34) 24 (18, 34)
PI3K+ TC4 n 6 (3, 14) 3 (1, 8) 5 (3, 10) 5 (2, 9) 0 (0, 0) 2 (0, 4) 1 (0, 2) 1 (0, 3) 0 (0, 2) 2 (0, 4) 0 (0, 0) 5 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.32 (0.18, 0.46) 0.41 (0.21, 0.49) 0.35 (0.19, 0.46) 0.3 (0.14, 0.45) NA (NA, NA) 0.39 (0.25, 0.48) 0.44 (0.35, 0.48) 0.41 (0.35, 0.47) 0.44 (0.38, 0.5) 0.41 (0.27, 0.47) NA (NA, NA) 0.38 (0.19, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.15 (0.115, 0.232) 0.169 (0.082, 0.398) 0.148 (0.11, 0.326) 0.153 (0.093, 0.662) 0 (0, 0) 0.145 (0.077, 0.319) 0.157 (0.034, 1.667) 0.187 (0.063, 1.261) 0.176 (0.054, 1.072) 0.189 (0.049, 0.487) NA (NA, NA) 0.125 (0.079, 0.263) 0.119 (0.119, 0.119) NA (NA, NA) 0.501 (0.215, 0.787) NA (NA, NA)
PI3K+ TC5 count 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92
PI3K+ TC5 time 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31) 17 (11, 31)
PI3K+ TC5 n 8 (4, 13) 4 (2, 8) 6 (3, 12) 5 (2, 9) 0 (0, 0) 1 (0, 3) 0 (0, 2) 1 (0, 2) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.35 (0.17, 0.48) 0.38 (0.22, 0.47) 0.38 (0.16, 0.48) 0.34 (0.16, 0.47) NA (NA, NA) 0.44 (0.29, 0.49) 0.43 (0.35, 0.49) 0.44 (0.35, 0.5) 0.44 (0.36, 0.48) 0.42 (0.27, 0.48) NA (NA, NA) 0.36 (0.21, 0.47) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.15 (0.109, 0.242) 0.142 (0.085, 0.492) 0.148 (0.093, 0.357) 0.137 (0.087, 0.286) 0.244 (0.244, 0.244) 0.161 (0, 0.4) 0.19 (0, 0.576) 0.148 (0, 1) 0.192 (0, 0.497) 0.168 (0, 0.693) NA (NA, NA) 0.134 (0.086, 0.383) 4.63 (1.12, 8.14) 0.216 (0.128, 0.303) 0.065 (0.065, 0.065) 0.122 (0.029, 0.592)